Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25443737 | 0.93 | ADAMTS5 (0.41) | ADAMTS5DRD3KCNH2HRH3KMO | |
| SCHEMBL25443736 | 0.92 | ADAMTS5 (0.43) | ADAMTS5DRD3KCNH2HRH3DRD2 | |
| SCHEMBL25443734 | 0.91 | ADAMTS5 (0.42) | ADAMTS5DRD3DRD2MAPK1ADAM17 | |
| SCHEMBL25443735 | 0.91 | ADAMTS5 (0.42) | ADAMTS5DRD3DRD2MAPK1ADAM17 | |
| SCHEMBL25443739 | 0.88 | SLC9A1 (0.46) | DRD3KCNH2HRH3KMOCCR1 | |
| SCHEMBL15840473 | 0.82 | ADAMTS5 (0.58) | ADAMTS5KCNH2HRH3MAPK1 | |
| SCHEMBL25444220 | 0.81 | DRD3 (0.48) | ADAMTS5DRD3DRD2MAPK1ADAM17 | |
| SCHEMBL25443732 | 0.79 | MEN1 (0.50) | ADAMTS5 | |
| SCHEMBL24712848 | 0.74 | NAMPT (0.55) | ADAMTS5KCNH2HRH3CCR1 | |
| SCHEMBL25443731 | 0.72 | MAPT (0.51) | ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230146870-A1 | METHOD TO QUANTIFY AFFINITY AND SELECTIVITY OF SMALL MOLECULES FOR PROTEINS IN LIVING CELLS | OHIO STATE INNOVATION FOUNDATION | 2023-05-11 | — | — | US | disclosed |
| US-20230146870-A1 | METHOD TO QUANTIFY AFFINITY AND SELECTIVITY OF SMALL MOLECULES FOR PROTEINS IN LIVING CELLS | OHIO STATE INNOVATION FOUNDATION | 2023-05-11 | — | — | US | disclosed |