Sugi Predict

Sugi Predict / Compounds / SCHEMBL254476

SCHEMBL254476

SCHEMBL254476

CC(C)c1cccc(Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PGR P06401 1/20 0.47
▸ HDAC4 P56524 2/20 0.47
▸ HDAC8 Q9BY41 2/20 0.47
▸ ALDH1A1 P00352 2/20 0.47
▸ MAPT P10636 2/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ PNMT P11086 1/20 0.47
▸ KDM4E B2RXH2 1/20 0.47
▸ MDM4 O15151 1/20 0.47
▸ CA1 P00915 1/20 0.47
▸ CA2 P00918 1/20 0.47
▸ TP53 P04637 1/20 0.47
▸ CYP3A4 P08684 1/20 0.47
▸ TYR P14679 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ ALOX15 P16050 1/20 0.47
▸ ALOX12 P18054 1/20 0.47
▸ CA5A P35218 1/20 0.47
▸ HTT P42858 1/20 0.47
▸ MDM2 Q00987 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29428797 1.00 PGR (0.47) PGRHDAC4HDAC8ALDH1A1MAPT
Ammonia Solution, Strong SCHEMBL16197665 0.98 PGR (0.46) PGRHDAC4HDAC8ALDH1A1MAPT
SCHEMBL27387727 0.89 PGR (0.53) PGRHDAC4HDAC8ALDH1A1MAPT
SCHEMBL8343239 0.87 RXRA (0.51) PGRHDAC4HDAC8ALDH1A1MAPT
SCHEMBL2601111 0.85 PNMT (0.47) ALDH1A1PNMTHPGDACP3AOC3
Diphenylamine SCHEMBL10435749 0.84 ADRB2 (0.50) PGRALDH1A1MAPTSMN1; SMN2CYP3A4
SCHEMBL30549338 0.83 PNMT (0.45) ALDH1A1PNMTHPGDACP3AOC3
SCHEMBL8094299 0.83 PNMT (0.45) ALDH1A1PNMTHPGDACP3AOC3
SCHEMBL23978651 0.82 PNMT (0.55) PNMTCYP3A4AOC3TSHRNPC1
SCHEMBL20012121 0.82 KIF11 (0.47) PGRALDH1A1MAPTSMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1826 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112592612-B Low-VOC acrylic resin coating and preparation method and application thereof 奔腾漆业(上海)有限公司 2022-03-25 — — CN claimed
WO-2024218632-A1 ERK PROTEIN KINASE INHIBITORS ARRAY BIOPHARMA INC. (US) 2024-10-24 — — WO disclosed
US-12043613-B2 Inhibitors of SARM1 DISARM THERAPEUTICS, INC. (US) 2024-07-23 — — US disclosed
US-12043613-B2 Inhibitors of SARM1 DISARM THERAPEUTICS, INC. (US) 2024-07-23 — — US disclosed
US-20240239772-A1 PROTEASE INHIBITORS AND METHODS OF USE THE CLEVELAND CLINIC FOUNDATION 2024-07-18 — — US disclosed
US-20240239772-A1 PROTEASE INHIBITORS AND METHODS OF USE THE CLEVELAND CLINIC FOUNDATION 2024-07-18 — — US disclosed
US-20240239792-A1 MODULATORS OF BCL-2 OR BCL-2/BCL-XL AND USES THEREOF ASIA VISION LIMITED (CN) 2024-07-18 — — US disclosed
US-12037323-B2 Uracil derivatives as Mer-AXL inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2024-07-16 — — US disclosed
US-12037323-B2 Uracil derivatives as Mer-AXL inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2024-07-16 — — US disclosed
EP-4157844-B1 4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER CENTRE NAT RECH SCIENT (FR) 2024-07-10 — — EP disclosed
US-5105036-A Friedel-Crafts catalyst and oxy-substituted cyclic amidines as cocatylsts; preferential formation of p-isomer BAYER AKTIENGESELLSCHAFT (DE) 1992-04-14 — — US disclosed
CN-1059718-A The weedicide that contains the  oxazolidinedione derivatives SAGAMI CHEM RES (JP) 1992-03-25 — — CN disclosed
EP-0442115-A1 Process for nucleus-chlorination of aromatic hydrocarbons BAYER AG (DE) 1991-08-21 — — EP disclosed
EP-0270138-B1 SUBSTITUTED 2-PHENYLIMINO-OXAZOLIDINE COMPOUNDS HAVING HERBICIDAL ACTIVITY DUPHAR INTERNATIONAL RESEARCH B.V (NL) 1991-05-29 — — EP disclosed
CN-86108416-A Oxazolidinedione derivative, process for producing the same, and herbicide containing the same — 1987-07-29 — — CN disclosed
EP-0012570-B1 SELECTIVE REACTION OF 1,4-DISUBSTITUTED BENZENE COMPOUNDS MOBIL OIL CORPORATION (US) 1983-10-12 — — EP disclosed
US-4371721-A ZEOLITES, CATALYSTS MOBIL OIL CORPORATION (US) 1983-02-01 — — US disclosed
EP-0012570-A2 Selective reaction of 1,4-disubstituted benzene compounds MOBIL OIL CORPORATION (US) 1980-06-25 — — EP disclosed
US-4133837-A Preferential aliphatic halogenation of ar-substituted alkylbenzenes THE DOW CHEMICAL COMPANY (US) 1979-01-09 — — US disclosed
US-4133837-A Preferential aliphatic halogenation of ar-substituted alkylbenzenes THE DOW CHEMICAL COMPANY (US) 1979-01-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240239792-A1 MODULATORS OF BCL-2 OR BCL-2/BCL-XL AND USES THEREOF BCL2, BCL2L2, BCL2L1 PGR 3203/4885HDAC4 1287/4885HDAC8 1206/4885
US-12037323-B2 Uracil derivatives as Mer-AXL inhibitors MERTK, DAPK1, AXL PGR 4264/4885HDAC4 3365/4885HDAC8 2511/4885
US-12043613-B2 Inhibitors of SARM1 SARM1, SMN1; SMN2, SARNP PGR 4665/4885HDAC4 1812/4885HDAC8 859/4885
US-20240239772-A1 PROTEASE INHIBITORS AND METHODS OF USE ACE2, ACE, TMPRSS2 PGR 2471/4885HDAC4 1540/4885HDAC8 1290/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.