SCHEMBL25459654

SCHEMBL25459654

c1ccc(-c2nc(-c3ccccc3)nc(-c3cccc4oc5cc(-c6cccc(-c7ccc8c(c7)sc7ccccc78)c6)ccc5c34)n2)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKDC P78527 1/20 0.36
ALDH1A1 P00352 2/20 0.33
MAPT P10636 2/20 0.33
HPGD P15428 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
RAB9A P51151 1/20 0.33
F9 P00740 1/20 0.33
ALOX5 P09917 1/20 0.33
HCRTR1 O43613 1/20 0.32
SLC9A1 P19634 1/20 0.32
TSHR P16473 2/20 0.32
KDM4E B2RXH2 1/20 0.32
TP53 P04637 1/20 0.32
NFKB1 P19838 1/20 0.32
MAPK1 P28482 1/20 0.32
NFKB2 Q00653 1/20 0.32
RELA Q04206 1/20 0.32
ATM Q13315 1/20 0.32
HSD17B10 Q99714 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25459238 0.99 PRKDC (0.35) PRKDCALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL24216567 0.99 PRKDC (0.36) PRKDCALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL23822565 0.98 PRKDC (0.36) PRKDCALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL25459235 0.98 PRKDC (0.36) PRKDCALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL23821586 0.96 MMP12 (0.35) PRKDCALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL25459332 0.96 PRKDC (0.38) PRKDCALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL25947253 0.96 PLA2G2A (0.36) PRKDCALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL25645977 0.96 PLA2G2A (0.36) PRKDCALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL25459329 0.94 PRKDC (0.37) PRKDCALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL25851901 0.94 PRKDC (0.35) PRKDCALDH1A1MAPTHPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240228523-A1 Metal complexes UDC IRELAND LTD (IE) 2024-07-11 US disclosed
US-20240228523-A1 Metal complexes UDC IRELAND LTD (IE) 2024-07-11 US disclosed
WO-2024033282-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2024-02-15 WO disclosed
US-20230331754-A1 MONONUCLEAR TRIPODAL HEXADENTATE IRIDIUM COMPLEXES FOR USE IN OLEDS UDC IRELAND LIMITED (IE) 2023-10-19 US disclosed
US-20230331754-A1 MONONUCLEAR TRIPODAL HEXADENTATE IRIDIUM COMPLEXES FOR USE IN OLEDS UDC IRELAND LIMITED (IE) 2023-10-19 US disclosed
US-20230295104-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2023-09-21 US disclosed
US-20230295104-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2023-09-21 US disclosed
US-20230157151-A1 ORGANIC ELECTROLUMINESCENT APPARATUS MERCK PATENT GMBH (DE) 2023-05-18 US disclosed
US-20230157151-A1 ORGANIC ELECTROLUMINESCENT APPARATUS MERCK PATENT GMBH (DE) 2023-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230331754-A1 MONONUCLEAR TRIPODAL HEXADENTATE IRIDIUM COMPLEXES FOR USE IN OLEDS OCIAD1, OCIAD2, NUDT1 PRKDC 2014/4885ALDH1A1 1063/4885MAPT 2387/4885
US-20240228523-A1 Metal complexes MCU, IMMT, SOD1 PRKDC 2960/4885ALDH1A1 1407/4885MAPT 1000/4885
US-20230295104-A1 MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES OR10J3, L1CAM, EPCAM PRKDC 3250/4885ALDH1A1 441/4885MAPT 753/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.