SCHEMBL25463453

SCHEMBL25463453

CC(=O)c1nn[nH]c1Oc1ccc(-c2ccccc2OC(F)F)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DRD1 P21728 2/20 0.47
▸ PPARG P37231 3/20 0.35
▸ PPARA Q07869 3/20 0.35
▸ DAGLA Q9Y4D2 2/20 0.35
▸ FFAR4 Q5NUL3 1/20 0.35
▸ ADRA2A P08913 2/20 0.35
▸ ADRA2B P18089 2/20 0.35
▸ ADRA2C P18825 2/20 0.35
▸ HSP90AA1 P07900 1/20 0.34
▸ HSP90AB1 P08238 1/20 0.34
▸ GRM2 Q14416 1/20 0.34
▸ NR1I2 O75469 1/20 0.34
▸ ROCK2 O75116 2/20 0.34
▸ ROCK1 Q13464 2/20 0.34
▸ CTSK P43235 1/20 0.34
▸ PTGS2 P35354 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ KCNN4 O15554 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24154465 0.91 DRD1 (0.47) DRD1PPARGPPARADAGLAFFAR4
SCHEMBL25464132 0.91 ALOX15 (0.39) DRD1PPARGPPARAFFAR4ADRA2A
SCHEMBL25463638 0.90 DRD1 (0.44) DRD1PPARGPPARADAGLAFFAR4
SCHEMBL25464951 0.84 PRKAB2 (0.41) PPARGPPARAFFAR4ADRA2AADRA2B
SCHEMBL21312605 0.75 DRD1 (0.43) DRD1DAGLAGRM2MEN1KMT2A
SCHEMBL24154823 0.75 DRD1 (0.43) DRD1DAGLAGRM2MEN1KMT2A
SCHEMBL25463456 0.74 ACACB (0.41) MEN1RAB9AKMT2A
SCHEMBL21312464 0.73 ALDH1A1 (0.40) DRD1MEN1KMT2A
SCHEMBL21312600 0.73 PPARG (0.43) PPARGPPARAHSP90AA1HSP90AB1
SCHEMBL21296864 0.73 PPARG (0.43) PPARGPPARAFFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS PHOENIX TISSUE REPAIR, INC. 2023-05-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS XDH, DUOX1, PNPO DRD1 3113/4885PPARG 914/4885PPARA 2155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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