SCHEMBL25470068

SCHEMBL25470068

COC[C@H]1O[C@@H](n2cc(C#CCNC(=O)CO)c(N)nc2=O)CC1O

nearest known ligand 0.48

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ DNMT1 P26358 5/20 0.42
▸ ADRB1 P08588 1/20 0.41
▸ DNMT3B Q9UBC3 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25469566 1.00 DNMT1 (0.42) DNMT1ADRB1DNMT3B
SCHEMBL25470067 0.91 DNMT1 (0.43) DNMT1ADRB1DNMT3B
SCHEMBL10081644 0.84 DNMT1 (0.49) DNMT1ADRB1DNMT3B
SCHEMBL25469641 0.84 DNMT1 (0.39) DNMT1
SCHEMBL25469568 0.83 CA2 (0.49) —
SCHEMBL25469567 0.82 TYMS (0.47) —
SCHEMBL25470064 0.82 TYMS (0.47) —
Phosphoric Acid SCHEMBL7659310 0.82 DNMT1 (0.47) DNMT1ADRB1DNMT3B
SCHEMBL6229380 0.81 POLG (0.46) —
SCHEMBL6229367 0.81 POLG (0.46) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230348968-A1 SHORT PENDANT ARM LINKERS FOR NUCLEOTIDES IN SEQUENCING APPLICATIONS ILLUMINA CAMBRIDGE LIMITED (GB) 2023-11-02 — — US disclosed
US-11655502-B2 Short pendant arm linkers for nucleotides in sequencing applications ILLUMINA CAMBRIDGE LIMITED (GB) 2023-05-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230348968-A1 SHORT PENDANT ARM LINKERS FOR NUCLEOTIDES IN SEQUENCING APPLICATIONS POLRMT, POLM, POLN DNMT1 221/4885ADRB1 4353/4885DNMT3B 337/4885
US-11655502-B2 Short pendant arm linkers for nucleotides in sequencing applications POLRMT, POLM, POLN DNMT1 221/4885ADRB1 4353/4885DNMT3B 337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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