Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | SI | P14410 | 2/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL468011 | 0.86 | TSHR (0.50) | ACHETSHRALDH1A1MAPK1THRB | |
| SCHEMBL28825810 | 0.85 | ACHE (0.40) | ACHETSHRALDH1A1TGFBR1 | |
| SCHEMBL27624206 | 0.83 | TSHR (0.48) | ACHETSHRALDH1A1MAPK1THRB | |
| Ethylene Glycol SCHEMBL27957390 | 0.83 | TSHR (0.48) | ACHETSHRALDH1A1MAPK1THRB | |
| Ethylene Glycol SCHEMBL7642479 | 0.80 | ALDH1A1 (0.45) | TSHRALDH1A1TET2EGLN1TGFBR1 | |
| SCHEMBL284254 | 0.80 | ALDH1A1 (0.62) | ACHETSHRALDH1A1APEX1THRB | |
| SCHEMBL10714186 | 0.80 | ALDH1A1 (0.62) | ACHETSHRALDH1A1APEX1THRB | |
| SCHEMBL2977390 | 0.79 | GAA (0.43) | ACHETSHRALDH1A1MAPK1LMNA | |
| SCHEMBL36395 | 0.78 | TSHR (0.41) | ACHETSHRALDH1A1THRBGAA | |
| SCHEMBL28002959 | 0.78 | ACHE (0.38) | ACHETSHRALDH1A1LMNAAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034384-B2 | Nitrite, nitrate reductase material on substrate; biocompatible of medical devices | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-10-11 | — | — | US | claimed |
| US-20080226686-A1 | GENERATION OF NITRIC OXIDE IN SITU AT SUBSTRATE/BLOOD INTERFACES AND REPRODUCIBLE NITRIC OXIDE SENSOR FOR DETECTING NITROSOTHIOLS | NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR | 2008-09-18 | — | — | US | claimed |
| US-8168423-B2 | Device for detecting nitrosothiol content in solution | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-05-01 | — | — | US | disclosed |
| US-8034384-B2 | Nitrite, nitrate reductase material on substrate; biocompatible of medical devices | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-10-11 | — | — | US | disclosed |
| US-20100276284-A1 | SENSOR FOR DETECTING NITROSOTHIOLS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-11-04 | — | — | US | disclosed |
| US-20080226686-A1 | GENERATION OF NITRIC OXIDE IN SITU AT SUBSTRATE/BLOOD INTERFACES AND REPRODUCIBLE NITRIC OXIDE SENSOR FOR DETECTING NITROSOTHIOLS | NATIONAL INSTITUTES OF HEALTH-DIRECTOR DEITR | 2008-09-18 | — | — | US | disclosed |
| US-7335383-B2 | Generation of nitric oxide in vivo from nitrite, nitrate or nitrosothiols endogenous in blood | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-02-26 | — | — | US | disclosed |
| US-7122698-B2 | Method for producing α-hydroxycarboxylate | NIPPON SHOKUBAI CO., LTD. (JP) | 2006-10-17 | — | — | US | disclosed |
| WO-2005094913-A1 | GENERATION OF NITRIC OXIDE IN SITU AT SUBSTRATE/BLOOD INTERFACES AND NITRIC OXIDE SENSOR FOR DETECTING NITROSOTHIOLS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2005-10-13 | — | — | WO | disclosed |
| EP-1571139-A1 | PROCESS FOR PRODUCING a-HYDROXYCARBOXYLIC ESTER | Nippon Shokubai Co., Ltd. (JP) | 2005-09-07 | — | — | EP | disclosed |
| US-20050090686-A1 | Method for producing alpha - hydroxycarboxylate | NIPPON SHOKUBAI CO., LTD. (JP) | 2005-04-28 | — | — | US | disclosed |
| US-20040224868-A1 | Generation of nitric oxide in situ at substrate/blood interfaces and reproducible nitric oxide sensor for detecting nitrosothiols | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090686-A1 | Method for producing alpha - hydroxycarboxylate | ADH1C, HCAR2, HAAO | ACHE 4025/4885TSHR 4306/4885ALDH1A1 39/4885 |
| US-20080226686-A1 | GENERATION OF NITRIC OXIDE IN SITU AT SUBSTRATE/BLOOD INTERFACES AND REPRODUCIBLE NITRIC OXIDE SENSOR FOR DETECTING NITROSOTHIOLS | SPR, NOS2, NOS1 | ACHE 263/4885TSHR 496/4885ALDH1A1 1233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.