Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LTA4H | P09960 | 5/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.57 |
| ▸ | KIF11 | P52732 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | BAX | Q07812 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11148692 | 0.90 | CA1 (0.52) | TSHRALDH1A1LTA4HMAPK14KIF11 | |
| SCHEMBL1685383 | 0.90 | CA1 (0.52) | TSHRALDH1A1LTA4HMAPK14KIF11 | |
| SCHEMBL23059790 | 0.88 | MEN1 (0.49) | TSHRALDH1A1LTA4HMAPK14KIF11 | |
| SCHEMBL11302861 | 0.88 | MAPK14 (0.52) | TSHRALDH1A1LTA4HMAPK14KIF11 | |
| SCHEMBL3106183 | 0.88 | MAPK14 (0.52) | TSHRALDH1A1LTA4HMAPK14KIF11 | |
| SCHEMBL29377645 | 0.87 | LTA4H (0.50) | TSHRALDH1A1LTA4HMAPK14KIF11 | |
| SCHEMBL25696606 | 0.84 | TSHR (0.46) | TSHRALDH1A1LTA4HMAPK14KIF11 | |
| SCHEMBL28638978 | 0.84 | L3MBTL1 (0.52) | TSHRALDH1A1MAPK14KIF11KMT2A | |
| SCHEMBL15372301 | 0.82 | LTA4H (0.52) | TSHRALDH1A1LTA4HMAPK14MEN1 | |
| SCHEMBL757765 | 0.82 | LTA4H (0.52) | TSHRLTA4HMAPK14MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | MERCK SHARP & DOHME LLC (US) | 2024-03-14 | — | — | US | claimed |
| US-4072500-A | Halogenated 4-trifluoromethyl-diphenyl-ether compounds and herbicidal compositions | BAYER AKTIENGESELLSCHAFT (DT) | 1978-02-07 | — | — | US | claimed |
| US-4023958-A | Halogenated 4-trifluoromethyl-diphenyl-ether compounds and herbicidal compositions | BAYER AKTIENGESELLSCHAFT (DT) | 1977-05-17 | — | — | US | claimed |
| US-4017300-A | Halogenated 4-trifluoromethyl-diphenyl-ether herbicidal compositions | BAYER AKTIENGESELLSCHAFT (DT) | 1977-04-12 | — | — | US | claimed |
| US-3957865-A | HERBICIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-18 | — | — | US | claimed |
| US-20230346753-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | VALO HEALTH, INC. | 2023-11-02 | — | — | US | disclosed |
| US-20210246147-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | Valo Health, LLC | 2021-08-12 | — | — | US | disclosed |
| EP-3587406-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |
| US-10870715-B2 | Solid polyaluminoxane composition, olefin polymerization catalyst, olefin polymer production method and solid polyaluminoxane composition production method | MITSUI CHEMICALS, INC. (JP) | 2020-12-22 | — | — | US | disclosed |
| US-10800750-B2 | Compounds and compositions for inhibition of FASN | FORMA THERAPEUTICS, INC. (US) | 2020-10-13 | — | — | US | disclosed |
| US-10772874-B2 | Compounds and compositions for the inhibition of NAMPT | VALO HEALTH, INC. | 2020-09-15 | — | — | US | disclosed |
| US-10647695-B2 | Compounds and compositions for the inhibition of NAMPT | FORMA TM, LLC (US) | 2020-05-12 | — | — | US | disclosed |
| US-4023958-A | Halogenated 4-trifluoromethyl-diphenyl-ether compounds and herbicidal compositions | BAYER AKTIENGESELLSCHAFT (DT) | 1977-05-17 | — | — | US | disclosed |
| US-4023958-A | Halogenated 4-trifluoromethyl-diphenyl-ether compounds and herbicidal compositions | BAYER AKTIENGESELLSCHAFT (DT) | 1977-05-17 | — | — | US | disclosed |
| US-4023958-A | Halogenated 4-trifluoromethyl-diphenyl-ether compounds and herbicidal compositions | BAYER AKTIENGESELLSCHAFT (DT) | 1977-05-17 | — | — | US | disclosed |
| US-4017300-A | Halogenated 4-trifluoromethyl-diphenyl-ether herbicidal compositions | BAYER AKTIENGESELLSCHAFT (DT) | 1977-04-12 | — | — | US | disclosed |
| US-4017300-A | Halogenated 4-trifluoromethyl-diphenyl-ether herbicidal compositions | BAYER AKTIENGESELLSCHAFT (DT) | 1977-04-12 | — | — | US | disclosed |
| US-4017300-A | Halogenated 4-trifluoromethyl-diphenyl-ether herbicidal compositions | BAYER AKTIENGESELLSCHAFT (DT) | 1977-04-12 | — | — | US | disclosed |
| US-3957865-A | HERBICIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-18 | — | — | US | disclosed |
| US-3957865-A | HERBICIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647695-B2 | Compounds and compositions for the inhibition of NAMPT | NAMPT, NNT, NQO1 | TSHR 2779/4885ALDH1A1 511/4885LTA4H 3143/4885 |
| US-20210246147-A1 | PIPERIDINE DERIVATIVES AND COMPOSITIONS FOR THE INHIBITION OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | NAMPT, NAPRT, NNMT | TSHR 3065/4885ALDH1A1 265/4885LTA4H 2579/4885 |
| US-10772874-B2 | Compounds and compositions for the inhibition of NAMPT | NAMPT, NNMT, NQO1 | TSHR 2846/4885ALDH1A1 994/4885LTA4H 2984/4885 |
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | TEAD2, TEAD3, TEAD4 | TSHR 551/4885ALDH1A1 483/4885LTA4H 1595/4885 |
| US-20230346753-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | NAMPT, NNMT, NQO1 | TSHR 2455/4885ALDH1A1 1273/4885LTA4H 2761/4885 |
| US-10800750-B2 | Compounds and compositions for inhibition of FASN | FASN, FABP1, SCD | TSHR 3610/4885ALDH1A1 1393/4885LTA4H 881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.