Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.35 |
| ▸ | GLS | O94925 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.33 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2550063 | 0.89 | NAMPT (0.40) | GPR119DDB1CRBNOXTRAVPR1A | |
| SCHEMBL2552066 | 0.86 | GPR119 (0.38) | GPR119DDB1CRBNOXTRAVPR1A | |
| SCHEMBL2556747 | 0.85 | HDAC1 (0.38) | GPR119DDB1CRBNOXTRAVPR1A | |
| SCHEMBL2336519 | 0.85 | DDB1 (0.35) | GPR119DDB1CRBNOXTRAVPR1A | |
| SCHEMBL2579657 | 0.84 | OXTR (0.36) | GPR119DDB1CRBNOXTRAVPR1A | |
| SCHEMBL2474689 | 0.84 | GPR119 (0.39) | MGLLGPR119ABHD6HRH3 | |
| SCHEMBL2573984 | 0.83 | HSD11B1 (0.35) | GLSABHD6HSD11B1PIM1 | |
| SCHEMBL2580300 | 0.83 | OXTR (0.36) | GPR119DDB1CRBNOXTRAVPR1A | |
| SCHEMBL2574746 | 0.83 | OXTR (0.34) | GPR119DDB1CRBNOXTRAVPR1A | |
| SCHEMBL2581930 | 0.83 | OXTR (0.34) | GPR119DDB1CRBNOXTRAVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552919-A1 | ARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F. Hoffmann-La Roche AG (CH) | 2013-02-06 | — | — | EP | disclosed |
| WO-2011120877-A1 | ARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-10-06 | — | — | WO | disclosed |