Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CHKA | P35790 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30938358 | 0.95 | CHRNB2 (0.37) | HTR6CHRM5CHRM3SIGMAR1CA2 | |
| SCHEMBL28206991 | 0.87 | GAA (0.35) | SIGMAR1CA2L3MBTL1POLBL3MBTL3 | |
| SCHEMBL15941744 | 0.85 | MEN1 (0.35) | SIGMAR1CA2TSHRL3MBTL1L3MBTL3 | |
| SCHEMBL30425541 | 0.85 | GAA (0.34) | SIGMAR1CA2L3MBTL1POLBL3MBTL3 | |
| SCHEMBL3153297 | 0.84 | CHRM5 (0.39) | HTR6CHRM5CHRM3SIGMAR1CA2 | |
| SCHEMBL3153126 | 0.79 | CHRM5 (0.36) | CHRM5CHRM3SIGMAR1CHRNB2CHRNA3 | |
| SCHEMBL29360628 | 0.79 | ALDH1A1 (0.39) | TSHRL3MBTL1L3MBTL3HPGD | |
| SCHEMBL28287138 | 0.79 | ALDH1A1 (0.38) | CHRM3SIGMAR1L3MBTL1L3MBTL3GAA | |
| SCHEMBL8776613 | 0.77 | HSD17B10 (0.41) | L3MBTL1HPGDEPHX1 | |
| SCHEMBL30425911 | 0.77 | L3MBTL3 (0.35) | L3MBTL1L3MBTL3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | disclosed |