Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959267 | 0.95 | KDM4E (0.40) | ALDH1A1KDM4EL3MBTL1L3MBTL3HSD17B10 | |
| SCHEMBL28206991 | 0.87 | GAA (0.35) | L3MBTL1L3MBTL3KMT2AMEN1HPGD | |
| SCHEMBL30425541 | 0.85 | GAA (0.34) | L3MBTL1L3MBTL3KMT2AMEN1HPGD | |
| SCHEMBL15941744 | 0.85 | MEN1 (0.35) | ALDH1A1KDM4EL3MBTL1L3MBTL3KMT2A | |
| SCHEMBL28287138 | 0.79 | ALDH1A1 (0.38) | ALDH1A1KDM4EL3MBTL1L3MBTL3TP53 | |
| SCHEMBL2552216 | 0.79 | HTR6 (0.39) | L3MBTL1L3MBTL3TSHRHPGD | |
| SCHEMBL28206590 | 0.78 | TSHR (0.49) | ALDH1A1L3MBTL1MAPTKMT2ATSHR | |
| SCHEMBL31411007 | 0.77 | USP2 (0.50) | ALDH1A1L3MBTL1HSD17B10KMT2AMEN1 | |
| SCHEMBL30425911 | 0.77 | L3MBTL3 (0.35) | ALDH1A1KDM4EL3MBTL1L3MBTL3KMT2A | |
| SCHEMBL3237715 | 0.75 | HSD11B1 (0.45) | ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022017442-A1 | BIFUNCTIONAL PROTEIN DEGRADATION-TARGETED CHIMERA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICINAL USE THEREOF | 恩瑞生物医药科技（上海）有限公司 | 2022-01-27 | — | — | WO | disclosed |