Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 1.00 |
| ▸ | RXRB | P28702 | 5/20 | 1.00 |
| ▸ | NPC1 | O15118 | 3/20 | 0.76 |
| ▸ | RAB9A | P51151 | 3/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.72 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.72 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.66 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.66 |
| ▸ | PTPRC | P08575 | 1/20 | 0.62 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8861229 | 1.00 | RXRA (1.00) | RXRARXRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8134318 | 0.91 | NR4A2 (0.85) | RXRARXRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL898771 | 0.87 | RXRA (0.77) | RXRARXRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17112801 | 0.87 | RXRA (0.77) | RXRARXRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9372929 | 0.87 | RXRA (0.77) | RXRARXRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16550312 | 0.86 | RXRA (0.76) | RXRARXRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28335896 | 0.86 | RAB9A (1.00) | RXRARXRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6520330 | 0.86 | RXRA (0.76) | RXRARXRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1186510 | 0.86 | RAB9A (1.00) | RXRARXRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12086470 | 0.85 | RAB9A (0.80) | RXRARXRBNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753371-B2 | Disulfiram derivatives as ALDH1A1 and MAGL inhibitors | BATTERJEE MEDICAL COLLEGE (SA) | 2023-09-12 | — | — | US | disclosed |
| US-20230174474-A1 | DISULFIRAM DERIVATIVES AS ALDH1A1 AND MAGL INHIBITORS | BATTERJEE MEDICAL COLLEGE (SA) | 2023-06-08 | — | — | US | disclosed |
| US-20230174475-A1 | DISULFIRAM DERIVATIVES AS ALDH1A1 AND MAGL INHIBITORS | BATTERJEE MEDICAL COLLEGE (SA) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11753371-B2 | Disulfiram derivatives as ALDH1A1 and MAGL inhibitors | ALDH1A1, ADH1A, ALDH3A1 | RXRA 1183/4885RXRB 1134/4885NPC1 493/4885 |
| US-20230174475-A1 | DISULFIRAM DERIVATIVES AS ALDH1A1 AND MAGL INHIBITORS | ADH1A, ALDH1A1, ALDH3A1 | RXRA 1829/4885RXRB 1802/4885NPC1 1090/4885 |
| US-20230174474-A1 | DISULFIRAM DERIVATIVES AS ALDH1A1 AND MAGL INHIBITORS | ALDH1A1, ADH1A, ALDH3A1 | RXRA 1183/4885RXRB 1134/4885NPC1 493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.