Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 4/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 2/20 | 0.35 |
| ▸ | AHR | P35869 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25567247 | 0.88 | MAPK14 (0.59) | MAPK14CSF1RALDH1A1NTRK1NTRK3 | |
| SCHEMBL25566088 | 0.78 | MAPK14 (0.51) | MAPK14CSF1RNTRK1NTRK3NTRK2 | |
| SCHEMBL25564759 | 0.72 | MAPK14 (0.58) | MAPK14CSF1RRAF1FLT3 | |
| SCHEMBL25567722 | 0.72 | MAPK14 (0.46) | MAPK14CSF1RRAF1TRPV1KDR | |
| SCHEMBL25567411 | 0.72 | ALDH1A1 (0.49) | MAPK14CSF1RALDH1A1NTRK1NTRK3 | |
| SCHEMBL25567190 | 0.71 | EGFR (0.49) | MAPK14CSF1RRAF1FLT3 | |
| SCHEMBL25567562 | 0.70 | HPGD (0.47) | MAPK14CSF1RRAF1TRPV1CNR2 | |
| SCHEMBL10576398 | 0.70 | CMA1 (0.49) | TRPV1CRBNTLK2CMA1AHR | |
| SCHEMBL22425097 | 0.70 | GRIN2D (0.53) | TLK2AHR | |
| SCHEMBL25566191 | 0.69 | MAPK14 (0.58) | MAPK14CSF1RRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078207-A1 | 6-POSITION-SUBSTITUTED INDOLINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | 南京中医药大学 | 2023-05-11 | — | — | WO | disclosed |