Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | NEK7 | Q8TDX7 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25566088 | 0.89 | MAPK14 (0.51) | MAPK14CSF1RRAF1NTRK1NTRK3 | |
| SCHEMBL25567264 | 0.88 | MAPK14 (0.45) | MAPK14CSF1RRAF1NTRK1NTRK3 | |
| SCHEMBL25564759 | 0.82 | MAPK14 (0.58) | MAPK14CSF1RRAF1FLT3MAPK13 | |
| SCHEMBL25567411 | 0.81 | ALDH1A1 (0.49) | MAPK14CSF1RRAF1NTRK1NTRK3 | |
| SCHEMBL25566546 | 0.79 | TRPV1 (0.57) | CSF1RTRPV1 | |
| SCHEMBL25566191 | 0.79 | MAPK14 (0.58) | MAPK14CSF1RRAF1MAPK13 | |
| SCHEMBL25565993 | 0.78 | ALDH1A1 (0.58) | ALDH1A1KDRFLT3 | |
| SCHEMBL25566469 | 0.76 | CMA1 (0.45) | MAPK14CSF1RRAF1KDRTRPV1 | |
| SCHEMBL13239491 | 0.75 | MAPK14 (0.78) | MAPK14CSF1RRAF1NTRK1NTRK3 | |
| SCHEMBL13234417 | 0.75 | MAPK14 (0.83) | MAPK14CSF1RRAF1NTRK1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078207-A1 | 6-POSITION-SUBSTITUTED INDOLINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | 南京中医药大学 | 2023-05-11 | — | — | WO | disclosed |