Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.47 |
| ▸ | RAF1 | P04049 | 3/20 | 0.43 |
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | KRAS | P01116 | 2/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25565806 | 0.82 | RAB9A (0.58) | MAPK14MAPK13BRAFCSF1RRET | |
| SCHEMBL25567247 | 0.81 | MAPK14 (0.59) | ALDH1A1MAPK14MAPK13RAF1BRAF | |
| SCHEMBL25567414 | 0.76 | HDAC3 (0.41) | — | |
| SCHEMBL155351 | 0.74 | HDAC3 (0.42) | — | |
| SCHEMBL154464 | 0.74 | HDAC3 (0.45) | — | |
| SCHEMBL154463 | 0.74 | HDAC3 (0.45) | — | |
| SCHEMBL152807 | 0.73 | HDAC3 (0.45) | — | |
| SCHEMBL25565793 | 0.73 | HDAC3 (0.38) | — | |
| SCHEMBL25566088 | 0.73 | MAPK14 (0.51) | MAPK14RAF1BRAFNTRK1NTRK3 | |
| SCHEMBL13235188 | 0.73 | MAPK14 (0.59) | ALDH1A1MAPK14MAPK13RAF1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078207-A1 | 6-POSITION-SUBSTITUTED INDOLINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | 南京中医药大学 | 2023-05-11 | — | — | WO | disclosed |