Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049857 | 0.82 | — | — | |
| SCHEMBL25587614 | 0.77 | GRIN2B (0.42) | — | |
| SCHEMBL25587000 | 0.76 | GRIN2B (0.43) | — | |
| SCHEMBL25587712 | 0.76 | GRIN2B (0.40) | — | |
| SCHEMBL15061923 | 0.76 | NOS3 (0.54) | NOS3NOS1NOS2CCR1CCR5 | |
| SCHEMBL20049966 | 0.73 | GRIN2B (0.43) | — | |
| SCHEMBL20049785 | 0.73 | GPBAR1 (0.39) | — | |
| SCHEMBL25584017 | 0.73 | GRIN2B (0.40) | — | |
| SCHEMBL25587638 | 0.72 | ESR2 (0.46) | — | |
| SCHEMBL25587627 | 0.71 | GRIN2B (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523311-B1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-07 | — | — | EP | disclosed |