SCHEMBL2558482

SCHEMBL2558482

CC(=O)c1ccc(N(CC(=O)O)N=O)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.45
RAB9A P51151 5/20 0.45
NPC1 O15118 3/20 0.45
MAPK1 P28482 2/20 0.45
KDM4E B2RXH2 1/20 0.45
KMT2A Q03164 2/20 0.41
HSD17B10 Q99714 1/20 0.41
LMNA P02545 2/20 0.41
MEN1 O00255 1/20 0.41
POLB P06746 1/20 0.41
GAA P10253 1/20 0.41
MCL1 Q07820 1/20 0.41
NOX1 Q9Y5S8 1/20 0.41
NR1I2 O75469 1/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
NOS3 P29474 2/20 0.38
NOS1 P29475 2/20 0.38
NPSR1 Q6W5P4 1/20 0.37
KEAP1 Q14145 1/20 0.37
NFE2L2 Q16236 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17352821 0.86 TSHR (0.44) RAB9ANPC1KMT2AMEN1POLB
SCHEMBL11751630 0.80 CA2 (0.41) MAPTMAPK1KDM4EKMT2AHSD17B10
SCHEMBL4322658 0.80 MAPT (0.49) MAPTRAB9ANPC1MAPK1KDM4E
SCHEMBL1404285 0.80 ALDH1A1 (0.46) RAB9ANPC1KMT2AMEN1POLB
SCHEMBL11692296 0.79 KEAP1 (0.41) MAPTRAB9ANPC1HSD17B10LMNA
SCHEMBL15939364 0.79 KEAP1 (0.41) KMT2AKEAP1NFE2L2L3MBTL1
SCHEMBL18360379 0.78 MAPT (0.53) MAPTRAB9ANPC1MAPK1KDM4E
SCHEMBL6172326 0.78 KEAP1 (0.57) KEAP1NFE2L2
SCHEMBL26558194 0.74 MAPT (0.61) MAPTRAB9ANPC1MAPK1KDM4E
SCHEMBL5443841 0.71 MAPT (0.47) MAPTRAB9ANPC1MAPK1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed