Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | PI4KA | P42356 | 1/20 | 0.45 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.45 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21199068 | 0.81 | ADORA2A (0.54) | CYP11B1CYP11B2TNFTSHRKDM4E | |
| SCHEMBL8830129 | 0.81 | CYP11B1 (0.50) | CYP11B1CYP11B2TNFTSHRKDM4E | |
| SCHEMBL20438539 | 0.81 | CYP11B1 (0.46) | CYP11B1CYP11B2TNFTSHRLMNA | |
| SCHEMBL11211782 | 0.79 | CYP11B1 (0.47) | CYP11B1CYP11B2TNFTSHRLMNA | |
| SCHEMBL7034716 | 0.79 | MEN1 (0.51) | CYP11B1CYP11B2LMNASMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL11295371 | 0.79 | CYP11B1 (0.47) | CYP11B1CYP11B2TNFTSHRKDM4E | |
| SCHEMBL8830053 | 0.79 | CYP11B1 (0.47) | CYP11B1CYP11B2TNFTSHRKDM4E | |
| Hydrochloric Acid SCHEMBL8830023 | 0.79 | CYP11B1 (0.47) | CYP11B1CYP11B2TNFTSHRKDM4E | |
| SCHEMBL11207135 | 0.78 | LMNA (0.50) | CYP11B1CYP11B2TNFTSHRKDM4E | |
| SCHEMBL4958156 | 0.78 | PKM (0.69) | CYP11B1CYP11B2TNFTSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266768-A1 | IRON-BASED COMPLEXES FOR USE IN THE CATALYSIS OF HYDROSILYLATION REACTIONS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2022-12-29 | — | — | WO | disclosed |
| EP-3774795-B1 | 4-(1H- IMIDAZOL- 5- YL) -1H-PYRROLO [2, 3-B] PYRIDINES FOR USE IN THE TREATMENT OF LEUKAEMIAS, LYMPHOMAS AND SOLID TUMORS | UNIV MASARYKOVA (CZ) | 2022-03-16 | — | — | EP | disclosed |
| WO-2019185631-A1 | 4—(1H— IMIDAZOL— 5— YL) -1H-PYRROLO [2, 3-B] PYRIDINES FOR USE IN THE TREATMENT OF LEUKAEMIAS, LYMPHOMAS AND SOLID TUMORS | MASARYKOVA UNIVERZITA (CZ) | 2019-10-03 | — | — | WO | disclosed |
| US-10278973-B2 | Hydroxyl purine compounds and use thereof | Guangdong Raynovent Biotech Co., Ltd. (CN) | 2019-05-07 | — | — | US | disclosed |
| US-20180140607-A1 | HYDROXYL PURINE COMPOUNDS AND USE THEREOF | Guangdong Raynovent Biotech Co., Ltd. (CN) | 2018-05-24 | — | — | US | disclosed |
| EP-3299371-A1 | HYDROXYL PURINE COMPOUNDS AND USE THEREOF | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-03-28 | — | — | EP | disclosed |
| US-8193224-B2 | Medicinal composition for prevention or treatment of parasitic protozoan infection | FUJIFILM CORPORATION (JP) | 2012-06-05 | — | — | US | disclosed |
| EP-1818334-B1 | ANTI-TRYPANOSOMIASIS AGENT | IHARA MASATAKA (JP) | 2011-11-02 | — | — | EP | disclosed |
| US-7795285-B2 | Anti-trypanosomiasis agent | FUJIFILM CORPORATION (JP) | 2010-09-14 | — | — | US | disclosed |
| US-20100113789-A1 | MEDICINAL COMPOSITION FOR PREVENTION OR TREATMENT OF PARASITIC PROTOZOAN INFECTION | Ihara, Masataka (JP) | 2010-05-06 | — | — | US | disclosed |
| US-20080076738-A1 | Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds | GILEAD SCIENCES, INC. | 2008-03-27 | — | — | US | disclosed |
| US-20080045574-A1 | thiazolidin-4-one derivatives used as antiprotozoa agents, or for the treatment of trypanosomiasis | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2008-02-21 | — | — | US | disclosed |
| EP-1818334-A1 | ANTI-TRYPANOSOMIASIS AGENT | Japan Science and Technology Agency (JP) | 2007-08-15 | — | — | EP | disclosed |
| EP-1800682-A1 | MEDICINAL COMPOSITION FOR PREVENTION OR TREATMENT OF PARASITIC PROTOZOAN INFECTION | Japan Science and Technology Agency (JP) | 2007-06-27 | — | — | EP | disclosed |
| US-20070027147-A1 | Biarylurea derivatives | MSD K.K. (JP) | 2007-02-01 | — | — | US | disclosed |
| US-20070027147-A1 | Biarylurea derivatives | MSD K.K. (JP) | 2007-02-01 | — | — | US | disclosed |
| CN-1684680-A | Imidazole alkaloid of lepidium meyenii and application thereof | PURE WORLD BOTAN INC (US) | 2005-10-19 | — | — | CN | disclosed |
| US-5670526-A | ANTIINFLAMMATORY AGENT, IMMUNOSUPPRESSANT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| US-4612324-A | Imidazole derivatives for treating joint diseases and Wilson's disease | HOFFMANN-LA ROCHE INC. (US) | 1986-09-16 | — | — | US | disclosed |
| EP-0118787-A1 | Alpha-amino-2-imidazole propionic-acid derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-09-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045574-A1 | thiazolidin-4-one derivatives used as antiprotozoa agents, or for the treatment of trypanosomiasis | TXN2, SQOR, TXNRD2 | CYP11B1 256/4885CYP11B2 288/4885TNF 4276/4885 |
| US-20180140607-A1 | HYDROXYL PURINE COMPOUNDS AND USE THEREOF | PNP, PDE7A, PDE2A | CYP11B1 172/4885CYP11B2 78/4885TNF 103/4885 |
| US-10278973-B2 | Hydroxyl purine compounds and use thereof | PNP, PDE7A, PDE2A | CYP11B1 172/4885CYP11B2 78/4885TNF 103/4885 |
| US-20100113789-A1 | MEDICINAL COMPOSITION FOR PREVENTION OR TREATMENT OF PARASITIC PROTOZOAN INFECTION | MRM1, NR1I3, RORA | CYP11B1 47/4885CYP11B2 80/4885TNF 3674/4885 |
| US-20070027147-A1 | Biarylurea derivatives | CDK6, CDK4, CCNI | CYP11B1 516/4885CYP11B2 781/4885TNF 3420/4885 |
| US-20080076738-A1 | Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds | TYMP, PNP, PIKFYVE | CYP11B1 3563/4885CYP11B2 3942/4885TNF 4815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.