Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 9/20 | 0.38 |
| ▸ | JAK2 | O60674 | 5/20 | 0.38 |
| ▸ | TYK2 | P29597 | 5/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | GRK6 | P43250 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | ICMT | O60725 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2570796 | 0.82 | MITF (0.49) | JAK1JAK2TYK2OPRD1JAK3 | |
| SCHEMBL1594682 | 0.80 | LMNA (0.45) | LMNAJAK1JAK2TYK2OPRD1 | |
| SCHEMBL2570702 | 0.76 | ADORA3 (0.39) | LMNA | |
| Hydrochloric Acid SCHEMBL23389304 | 0.72 | CYP11B2 (0.35) | LMNAKCNH2DYRK1AICMT | |
| SCHEMBL14786484 | 0.72 | CYP11B2 (0.35) | LMNAKCNH2DYRK1AICMT | |
| SCHEMBL14786459 | 0.71 | POLB (0.46) | LMNA | |
| SCHEMBL7607398 | 0.68 | LMNA (0.43) | LMNAPTGER4ICMT | |
| Hydrochloric Acid SCHEMBL23389330 | 0.66 | MEN1 (0.35) | LMNAJAK2KCNH2DYRK1A | |
| SCHEMBL23389350 | 0.66 | MAPT (0.38) | LMNAOPRD1DYRK1A | |
| SCHEMBL23389316 | 0.66 | MEN1 (0.35) | LMNAJAK2KCNH2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2755964-B1 | SULFONIC ACID SALTS OF HETEROCYCLYLAMIDE-SUBSTITUTED IMIDAZOLES | AICURIS ANTI INFECTIVE CURES GMBH (DE) | 2016-06-22 | — | — | EP | disclosed |
| EP-2755964-A1 | SULFONIC ACID SALTS OF HETEROCYCLYLAMIDE-SUBSTITUTED IMIDAZOLES | AiCuris GmbH & Co. KG (DE) | 2014-07-23 | — | — | EP | disclosed |
| WO-2013037812-A1 | SULFONIC ACID SALTS OF HETEROCYCLYLAMIDE-SUBSTITUTED IMIDAZOLES | AICURIS GMBH & CO. KG (DE) | 2013-03-21 | — | — | WO | disclosed |
| EP-1732901-B1 | ANTIVIRAL 4-AMINOCARBONYLAMINO-SUBSTITUTED IMIDAZOLE COMPOUND | AICURIS GMBH & CO KG (DE) | 2011-11-02 | — | — | EP | disclosed |
| EP-1853582-B1 | HETEROCYCLYLAMIDE-SUBSTITUTED IMIDAZOLES | AICURIS GMBH & CO KG (DE) | 2009-10-21 | — | — | EP | disclosed |
| EP-1853582-A2 | HETEROCYCLYLAMIDE-SUBSTITUTED IMIDAZOLES | AiCuris GmbH & Co. KG (DE) | 2007-11-14 | — | — | EP | disclosed |
| EP-1732901-A1 | ANTIVIRAL 4-AMINOCARBONYLAMINO-SUBSTITUTED IMIDAZOLE COMPOUND | Bayer HealthCare AG (DE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2006089664-A2 | HETEROCYCLYLAMIDE-SUBSTITUTED IMIDAZOLES | AICURIS GMBH & CO. KG (DE) | 2006-08-31 | — | — | WO | disclosed |
| WO-2005092865-A1 | ANTIVIRAL 4-AMINOCARBONYLAMINO-SUBSTITUTED IMIDAZOLE COMPOUND | BAYER HEALTHCARE AG (DE) | 2005-10-06 | — | — | WO | disclosed |