Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 4/20 | 0.55 |
| ▸ | MAOB | P27338 | 4/20 | 0.55 |
| ▸ | PRF1 | P14222 | 9/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24102359 | 0.84 | MAOA (0.55) | MAPTLMNAGAAMAOAMAOB | |
| SCHEMBL14726085 | 0.81 | MAPT (0.41) | MAPTLMNAGAAMAOAMAOB | |
| SCHEMBL30372059 | 0.76 | MAPT (0.61) | MAPTLMNAGAAMAOAMAOB | |
| SCHEMBL87174 | 0.76 | MAPT (0.61) | MAPTLMNAGAAMAOAMAOB | |
| SCHEMBL29580985 | 0.76 | LMNA (1.00) | MAPTLMNAGAAMAOAMAOB | |
| SCHEMBL855289 | 0.76 | MAPT (0.61) | MAPTLMNAGAAMAOAMAOB | |
| SCHEMBL31621082 | 0.76 | MAPT (0.61) | MAPTLMNAGAAMAOAMAOB | |
| SCHEMBL365201 | 0.76 | MAPT (0.61) | MAPTLMNAGAAMAOAMAOB | |
| SCHEMBL4170867 | 0.76 | MAPT (0.61) | MAPTLMNAGAAMAOAMAOB | |
| SCHEMBL29492902 | 0.76 | MAPT (0.61) | MAPTLMNAGAAMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012029942-A1 | CYCLIC AMIDE DERIVATIVE | 大日本住友製薬株式会社 (JP) | 2012-03-08 | — | — | WO | disclosed |
| WO-2011061168-A1 | ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2011-05-26 | — | — | WO | disclosed |