SCHEMBL257142

SCHEMBL257142

Nc1nc(-c2cccc(C(F)(F)F)c2)c(C(=O)c2ccccc2Cl)s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORB Q92753 20/20 1.00
RORC P51449 4/20 0.84

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL257572 0.85 RORB (1.00) RORBRORC
SCHEMBL257608 0.84 RORB (0.83) RORBRORC
SCHEMBL257271 0.81 RORB (0.76) RORBRORC
SCHEMBL6258242 0.81 RORB (0.69) RORBRORC
SCHEMBL2492021 0.81 RORB (0.69) RORBRORC
SCHEMBL174906 0.80 RORB (0.74) RORBRORC
SCHEMBL168526 0.79 RORB (0.70) RORBRORC
SCHEMBL257437 0.79 RORB (0.76) RORBRORC
SCHEMBL257434 0.76 RORB (0.79) RORBRORC
SCHEMBL257203 0.76 RORB (0.67) RORBRORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012027965-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2012-03-08 WO disclosed