Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 9/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.41 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.39 |
| ▸ | PIP4K2B | P78356 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | BLK | P51451 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 2/20 | 0.39 |
| ▸ | CCNH | P51946 | 2/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
| ▸ | CDK14 | O94921 | 1/20 | 0.38 |
| ▸ | CCNY | Q8ND76 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25735905 | 0.79 | NOX1 (0.49) | — | |
| SCHEMBL31335904 | 0.71 | MELK (0.50) | ITKBTK | |
| SCHEMBL31336083 | 0.71 | KDM4E (0.46) | ACKR3EGFRERBB2PIP4K2APIP4K2B | |
| Hydrochloric Acid SCHEMBL31335956 | 0.70 | ITGB3 (0.50) | — | |
| SCHEMBL16665103 | 0.70 | NMT1 (0.58) | EGFRPIP4K2APIP4K2BITKCDK14 | |
| SCHEMBL20764166 | 0.70 | CDK14 (0.47) | BRD4EGFRERBB2PIP4K2APIP4K2B | |
| SCHEMBL23432509 | 0.70 | PKM (0.44) | — | |
| SCHEMBL13067824 | 0.69 | EGFR (0.47) | EGFRERBB2PIP4K2APIP4K2BKDR | |
| SCHEMBL13389249 | 0.69 | EGFR (0.55) | EGFRERBB2PIP4K2APIP4K2BITK | |
| SCHEMBL16665163 | 0.69 | ITK (0.64) | ACKR3EGFRERBB2PIP4K2APIP4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | THE BROAD INSTITUTE, INC. | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192904-A1 | BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF | ERBB2, ACP1, TK1 | BRD4 2517/4885ACKR3 2105/4885EGFR 220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.