SCHEMBL257409

SCHEMBL257409

COC(=O)c1cccc(Br)c1C

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.50
TSHR P16473 2/20 0.50
ALDH1A1 P00352 4/20 0.48
CFTR P13569 1/20 0.48
HSD17B10 Q99714 1/20 0.48
FFAR4 Q5NUL3 1/20 0.48
SLC6A3 Q01959 1/20 0.47
CA1 P00915 2/20 0.47
CA2 P00918 2/20 0.47
CA9 Q16790 2/20 0.47
CA5A P35218 1/20 0.47
POLB P06746 2/20 0.47
KDM4E B2RXH2 2/20 0.47
ATM Q13315 1/20 0.47
MYC P01106 1/20 0.46
KMT2A Q03164 3/20 0.46
MEN1 O00255 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30280732 1.00 LMNA (0.50) LMNATSHRALDH1A1CFTRHSD17B10
SCHEMBL3511612 0.86 LMNA (0.59) LMNATSHRALDH1A1CFTRHSD17B10
SCHEMBL20146043 0.82 CA1 (0.44) LMNATSHRALDH1A1CFTRHSD17B10
SCHEMBL29279663 0.82 TSHR (0.52) LMNATSHRALDH1A1CFTRHSD17B10
SCHEMBL29433258 0.82 TSHR (0.61) LMNATSHRALDH1A1CFTRHSD17B10
SCHEMBL23659 0.82 TSHR (0.61) LMNATSHRALDH1A1CFTRHSD17B10
SCHEMBL265052 0.81 TSHR (0.63) TSHRALDH1A1HSD17B10CA1CA2
SCHEMBL30906644 0.81 NPC1 (0.40) LMNATSHRALDH1A1HSD17B10SLC6A3
SCHEMBL27208786 0.81 NPC1 (0.40) LMNATSHRALDH1A1HSD17B10SLC6A3
SCHEMBL1962462 0.81 CA1 (0.53) LMNATSHRALDH1A1CFTRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 522 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3692101-B1 BRILLIANT BLUE (BBG) DYE DERIVATIVES AND STAINING COMPOSITIONS COMPRISING THE SAME FOR SELECTIVELY STAINING BIOLOGICAL SUBSTRATES ALFA INSTR S R L (IT) 2022-01-12 EP claimed
EP-3692101-A1 BRILLIANT BLUE (BBG) DYE DERIVATIVES AND STAINING COMPOSITIONS COMPRISING THE SAME FOR SELECTIVELY STAINING BIOLOGICAL SUBSTRATES Alfa Instruments S.r.l. (IT) 2020-08-12 EP claimed
WO-2019068935-A1 BRILLIANT BLUE (BBG) DYE DERIVATIVES AND STAINING COMPOSITIONS COMPRISING THE SAME FOR SELECTIVELY STAINING BIOLOGICAL SUBSTRATES ALFA INSTRUMENTS S.R.L. (IT) 2019-04-11 WO claimed
WO-2026107328-A1 AGONISTS OF PARATHYROID HORMONE 1 AND INCRETIN RECEPTORS SEPTERNA, INC. (US) 2026-05-21 WO disclosed
CN-122010947-A Antagonists of adenosine A2a receptors 阿道尔克斯治疗有限公司 2026-05-12 CN disclosed
US-12617796-B2 Antagonists of the adenosine A2a receptor JANSSEN PHARMACEUTICA NV (BE) 2026-05-05 US disclosed
US-12583862-B2 Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway NURIX THERAPEUTICS, INC. (US) 2026-03-24 US disclosed
US-12582722-B2 Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway NURIX THERAPEUTICS, INC. (US) 2026-03-24 US disclosed
US-12582641-B2 Sulfur-containing compound based on glutarimide skeleton and application thereof SHANGHAITECH UNIVERSITY (CN) 2026-03-24 US disclosed
US-12569564-B2 Spirocyclic MDM2 modulator and uses thereof NEWAVE PHARMACEUTICAL INC. (US) 2026-03-10 US disclosed
EP-4703358-A1 BENZO SIX-MEMBERED HETEROCYCLIC GSPT1 PROTEIN DEGRADATION AGENT AND USE THEREOF China Pharmaceutical University (CN) 2026-03-04 EP disclosed
US-20030096841-A1 Isoindole-imide compounds, compositions, and uses thereof CELGENE CORPORATION 2003-05-22 US disclosed
US-6518257-B1 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-02-11 US disclosed
WO-2002059106-A1 ISOINDOLE-IMIDE COMPOUNDS, COMPOSITIONS, AND USES THEREOF CELGENE CORPORATION (US) 2002-08-01 WO disclosed
EP-1227086-A1 1-SUBSTITUTED PHENYL-1-(1H-IMIDAZOL-4-YL) ALCOHOLS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2002-07-31 EP disclosed
US-6242644-B1 FOR TREATING THROMBOSIS, APOPLEXY, CARDIAC INFARCTION, INFLAMATION AND ARTHEROSCLEROSIS HOFFMANN-LA ROCHE INC. 2001-06-05 US disclosed
US-5387582-A Immunomodulators; useful in treatment and prophylaxis of diabetes, hypertension, rheumatoid arthritis and asthma LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESEL SKAB) (DK) 1995-02-07 US disclosed
WO-1995003300-A1 HETEROARYL QUINOLINES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC. (CA) 1995-02-02 WO disclosed
EP-0506794-A1 NOVEL VITAMIN D ANALOGUES. LEO PHARM PROD LTD (DK) 1992-10-07 EP disclosed
WO-1991009841-A1 NOVEL VITAMIN D ANALOGUES Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 1991-07-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12582641-B2 Sulfur-containing compound based on glutarimide skeleton and application thereof SUCNR1, SRD5A1, GLS LMNA 1605/4885TSHR 1830/4885ALDH1A1 697/4885
US-12617796-B2 Antagonists of the adenosine A2a receptor ADORA2A, ADORA2B, ADORA3 LMNA 3604/4885TSHR 81/4885ALDH1A1 1348/4885
US-20030096841-A1 Isoindole-imide compounds, compositions, and uses thereof TNF, IKZF3, IKZF1 LMNA 3635/4885TSHR 1322/4885ALDH1A1 2514/4885
US-12582722-B2 Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway PSMB2, PSME3, PSMB3 LMNA 2661/4885TSHR 2192/4885ALDH1A1 4614/4885
US-12569564-B2 Spirocyclic MDM2 modulator and uses thereof MDM2, TP53, XIAP LMNA 1263/4885TSHR 1018/4885ALDH1A1 1320/4885
US-12583862-B2 Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway BTK, PSMB2, PSME3 LMNA 2427/4885TSHR 3211/4885ALDH1A1 4714/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.