SCHEMBL25747864

SCHEMBL25747864

COc1ccc2[nH]cc(C(=O)C(=O)N(C)C(C)C)c2c1C

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ HTR1A P08908 1/20 0.35
▸ MTNR1A P48039 1/20 0.34
▸ MTNR1B P49286 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ LMNA P02545 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ HIF1A Q16665 1/20 0.34
▸ NR4A2 P43354 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31077729 0.87 MAPK14 (0.39) HTR1AMTNR1AMTNR1BALDH1A1LMNA
SCHEMBL25747852 0.87 MAPK14 (0.39) HTR1AMTNR1AMTNR1BALDH1A1LMNA
SCHEMBL25422956 0.87 HTR1A (0.47) HTR1AMTNR1AMTNR1BALDH1A1LMNA
SCHEMBL25747868 0.85 MEN1 (0.36) MTNR1AMTNR1BALDH1A1
SCHEMBL25436706 0.83 ALDH1A1 (0.38) HTR1AMTNR1AMTNR1BALDH1A1LMNA
SCHEMBL25423229 0.83 NR4A2 (0.33) ALDH1A1LMNAMAPTNR4A2
SCHEMBL25436610 0.81 NR4A2 (0.36) MTNR1AMTNR1BNR4A2
SCHEMBL31077662 0.79 GABRP (0.41) MTNR1AMTNR1BLMNAMAPTNR4A2
SCHEMBL25289183 0.79 GABRP (0.41) MTNR1AMTNR1BLMNAMAPTNR4A2
SCHEMBL17417724 0.77 PRKAB2 (0.46) MTNR1AMTNR1BALDH1A1MAPTNR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250101038-A1 COMPOUNDS Psylo Pty Ltd (AU) 2025-03-27 — — US disclosed
CN-118715204-A Compounds of formula (I) 普赛洛私人有限公司 2024-09-27 — — CN disclosed
WO-2023115166-A1 COMPOUNDS Psylo Pty Ltd (AU) 2023-06-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250101038-A1 COMPOUNDS NLN, SLC18A2, PYGB HTR1A 185/4885MTNR1A 888/4885MTNR1B 461/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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