Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | FOS | P01100 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | JUN | P05412 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31666050 | 1.00 | LDHA (0.55) | LDHAALOX15ALOX12CA2FOS | |
| SCHEMBL2568835 | 1.00 | LDHA (0.55) | LDHAALOX15ALOX12CA2FOS | |
| SCHEMBL4247499 | 0.92 | LDHA (0.60) | LDHAALOX15ALOX12CA2ALDH1A1 | |
| SCHEMBL18526398 | 0.89 | ALOX15 (0.57) | LDHAALOX15ALOX12CA2FOS | |
| SCHEMBL218706 | 0.86 | ALOX15 (0.43) | LDHAALOX15ALOX12CA2FOS | |
| SCHEMBL218707 | 0.86 | REN (0.47) | — | |
| SCHEMBL14777605 | 0.86 | REN (0.47) | — | |
| SCHEMBL5792794 | 0.83 | LDHA (0.58) | LDHAALOX15ALOX12CA2FOS | |
| SCHEMBL14221347 | 0.83 | LDHA (0.51) | LDHAALOX15ALOX12CA2ALDH1A1 | |
| SCHEMBL8076708 | 0.81 | LDHA (0.60) | LDHAALOX15ALOX12CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210324344-A1 | ENONE REDUCTASES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2021-10-21 | — | — | US | disclosed |
| US-10995321-B2 | Enone reductases | CODEXIS, INC. (US) | 2021-05-04 | — | — | US | disclosed |
| US-20200040311-A1 | ENONE REDUCTASES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2020-02-06 | — | — | US | disclosed |
| US-20180312815-A1 | ENONE REDUCTASES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2018-11-01 | — | — | US | disclosed |
| US-10035988-B2 | Enone reductases | CODEXIS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20170175087-A1 | ENONE REDUCTASES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2017-06-22 | — | — | US | disclosed |
| US-9617568-B2 | Enone reductases | CODEXIS, INC. (US) | 2017-04-11 | — | — | US | disclosed |
| US-20160273007-A1 | ENONE REDUCTASES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2016-09-22 | — | — | US | disclosed |
| US-9388438-B2 | Enone reductases | CODEXIS, INC. (US) | 2016-07-12 | — | — | US | disclosed |
| US-20150315613-A1 | ENONE REDUCTASES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2015-11-05 | — | — | US | disclosed |
| US-9121045-B2 | Enone reductases | CODEXIS, INC. (US) | 2015-09-01 | — | — | US | disclosed |
| EP-2382308-B1 | ENONE REDUCTASES | CODEXIS INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-20150031095-A1 | ENONE REDUCTASES | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2015-01-29 | — | — | US | disclosed |
| US-8883475-B2 | Enone reductases | CODEXIS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-20130115663-A1 | ENONE REDUCTASES | CODEXIS, INC. (US) | 2013-05-09 | — | — | US | disclosed |
| US-8329438-B2 | Enone reductases | CODEXIS, INC. (US) | 2012-12-11 | — | — | US | disclosed |
| EP-2382308-A2 | ENONE REDUCTASES | Codexis, Inc. (US) | 2011-11-02 | — | — | EP | disclosed |
| US-20100190218-A1 | ENONE REDUCTASES | CODEXIS, INC. (US) | 2010-07-29 | — | — | US | disclosed |
| WO-2010075574-A2 | ENONE REDUCTASES | CODEXIS, INC. (US) | 2010-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312815-A1 | ENONE REDUCTASES | ENO1, DCXR, RRM2B | LDHA 811/4885ALOX15 2672/4885ALOX12 2744/4885 |
| US-10995321-B2 | Enone reductases | ENO1, DCXR, RRM2B | LDHA 811/4885ALOX15 2672/4885ALOX12 2744/4885 |
| US-20200040311-A1 | ENONE REDUCTASES | ENO1, DCXR, RRM2B | LDHA 811/4885ALOX15 2672/4885ALOX12 2744/4885 |
| US-20210324344-A1 | ENONE REDUCTASES | ENO1, DCXR, RRM2B | LDHA 811/4885ALOX15 2672/4885ALOX12 2744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.