Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NHERF1 | O14745 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23833734 | 0.93 | LMNA (0.44) | ALOX5TBXA2RSMN1; SMN2MAPTKMT2A | |
| SCHEMBL25754907 | 0.91 | IDH1 (0.48) | NHERF1TBXA2RSMN1; SMN2MAPTKMT2A | |
| SCHEMBL25754910 | 0.77 | NHERF1 (0.48) | NHERF1TBXA2RSMN1; SMN2MAPTKMT2A | |
| SCHEMBL25754703 | 0.73 | CYP19A1 (0.44) | TBXA2RSMN1; SMN2MAPTKMT2ATDP1 | |
| SCHEMBL23833751 | 0.72 | TBXA2R (0.47) | NHERF1TBXA2RSMN1; SMN2MAPTKMT2A | |
| SCHEMBL31001013 | 0.72 | ALDH1A1 (0.46) | SMN1; SMN2MAPTKMT2ALMNAMAPK1 | |
| SCHEMBL19332218 | 0.72 | ALDH1A1 (0.46) | SMN1; SMN2MAPTKMT2ALMNAMAPK1 | |
| SCHEMBL23833717 | 0.71 | CA2 (0.49) | TBXA2RMAPTKMT2ALMNATDP1 | |
| SCHEMBL23833756 | 0.70 | POLB (0.56) | TBXA2RSMN1; SMN2MAPTKMT2ALMNA | |
| SCHEMBL16064422 | 0.69 | ALDH1A1 (0.54) | SMN1; SMN2MAPTKMT2ALMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | US | disclosed |
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | AMATHUS THERAPEUTICS, INC. (US) | 2023-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230174523-A1 | BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF | TRAP1, PINK1, TP53BP1 | NHERF1 960/4885ALOX5 4318/4885TBXA2R 3207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.