SCHEMBL2578611

SCHEMBL2578611

CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C#N)cc1

nearest known ligand 0.76

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 2/20 0.67
AGTR2 P50052 2/20 0.67
PPARG P37231 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL987699 0.89 AGTR1 (0.57) AGTR1AGTR2PPARG
SCHEMBL684085 0.87 AGTR1 (0.71) AGTR1AGTR2PPARG
SCHEMBL12737295 0.87 PPARG (0.64) AGTR1AGTR2PPARG
SCHEMBL5328080 0.86 PPARG (0.61) AGTR1AGTR2PPARG
SCHEMBL7430230 0.86 PPARG (0.63) AGTR1AGTR2PPARG
SCHEMBL8566093 0.84 AGTR1 (0.68) AGTR1AGTR2
SCHEMBL7312663 0.84 AGTR1 (0.68) AGTR1AGTR2PPARG
SCHEMBL8207617 0.83 PPARG (0.60) AGTR1PPARG
SCHEMBL12593005 0.83 AGTR2 (0.74) AGTR1AGTR2PPARG
SCHEMBL7310636 0.83 AGTR1 (0.66) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8048904-B2 Process for the preparation of olmesartan medoxomil MATRIX LABORATORIES LTD. (IN) 2011-11-01 US disclosed
US-20090281327-A1 PROCESS FOR THE PREPARATION OF OLMESARTAN MEDOXOMIL MATRIX PHARMACORP PRIVATE LIMITED (IN) 2009-11-12 US disclosed
EP-0796852-B1 Process for preparation of 5-substituted tetrazoles TOYO KASEI KOGYO CO LTD (JP) 2001-10-24 EP disclosed
US-6040454-A REACTING 1-(CYANOBIPHENYLMETHYL)IMIDAZOLE DERIVATIVE WITH AN ALKALI OR ALKALINE EARTH METAL AZIDE SALT IN AN AROMATIC HYDROCARBON SOLVENT IN PRESENCE OF AN AMINE SALT TOYO KASEI KOGYO COMPANY LIMITED (JP) 2000-03-21 US disclosed
CN-1045770-C Process for preparing 1-biphenylmethylimidazole derivatives SANKYO CO (JP) 1999-10-20 CN disclosed
US-5744612-A Process for preparation of 5- substituted tetrazoles TOYO KASEI KOGYO COMPANY LIMITED (JP) 1998-04-28 US disclosed
EP-0796852-A1 Process for preparation of 5-substituted tetrazoles Toyo Kasei Kogyo Company Limited (JP) 1997-09-24 EP disclosed
EP-0503785-A1 1-Biphenylimidazole derivatives, their preparation and their therapeutic use Sankyo Company Limited (JP) 1992-09-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090281327-A1 PROCESS FOR THE PREPARATION OF OLMESARTAN MEDOXOMIL MED1, TET1, AGTR1 AGTR1 3/4885AGTR2 5/4885PPARG 2624/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.