Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | GOT1 | P17174 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2579157 | 0.77 | SMN1; SMN2 (0.42) | TRPV1MAPTSMN1; SMN2EGLN1KMT2A | |
| SCHEMBL2586748 | 0.77 | GAA (0.41) | MAPTSMN1; SMN2EGLN1KMT2ALMNA | |
| SCHEMBL4260241 | 0.75 | SMN1; SMN2 (0.46) | SMN1; SMN2EGLN1KMT2A | |
| SCHEMBL2579176 | 0.74 | SMN1; SMN2 (0.41) | MAPTSMN1; SMN2EGLN1KMT2APOLB | |
| SCHEMBL2587146 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2EGLN1KMT2ALMNAALDH1A1 | |
| SCHEMBL2588885 | 0.73 | PKM (0.55) | MAPTSMN1; SMN2POLBLMNAALDH1A1 | |
| SCHEMBL2584665 | 0.71 | NPC1 (0.48) | MAPTSMN1; SMN2KMT2ANPC1GAA | |
| SCHEMBL2583662 | 0.71 | BCHE (0.47) | — | |
| SCHEMBL2582179 | 0.70 | RAB9A (0.47) | MAPTSMN1; SMN2KMT2APOLBALDH1A1 | |
| SCHEMBL2587147 | 0.69 | CRHBP (0.42) | SMN1; SMN2KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |