Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | CCR2 | P41597 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2581672 | 0.88 | DRD4 (0.53) | BCHEACHEBACE1DRD4HTR2A | |
| SCHEMBL2585658 | 0.84 | CCR2 (0.46) | DRD4HTR2AHDAC3HDAC4HDAC7 | |
| SCHEMBL2586918 | 0.84 | CCR3 (0.51) | — | |
| SCHEMBL2587146 | 0.81 | SMN1; SMN2 (0.43) | HDAC3HDAC4HDAC7HDAC9HDAC5 | |
| SCHEMBL2579176 | 0.80 | SMN1; SMN2 (0.41) | EPHX2 | |
| SCHEMBL2585643 | 0.79 | MEN1 (0.43) | — | |
| SCHEMBL4260241 | 0.79 | SMN1; SMN2 (0.46) | HDAC3HDAC4HDAC7HDAC9HDAC5 | |
| SCHEMBL2586748 | 0.76 | GAA (0.41) | EPHX2 | |
| SCHEMBL2579157 | 0.75 | SMN1; SMN2 (0.42) | HDAC3HDAC4HDAC7HDAC9HDAC5 | |
| SCHEMBL5531317 | 0.72 | AKR1C3 (0.43) | HDAC3HDAC4HDAC7HDAC9HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |