Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260241 | 0.79 | SMN1; SMN2 (0.46) | EGLN1SMN1; SMN2MEN1KMT2ALIPE | |
| SCHEMBL2587146 | 0.79 | SMN1; SMN2 (0.43) | EGLN1SMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL2588885 | 0.79 | PKM (0.55) | GAATSHRSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2579176 | 0.78 | SMN1; SMN2 (0.41) | GAAEGLN1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2579157 | 0.77 | SMN1; SMN2 (0.42) | GAATSHREGLN1SMN1; SMN2MAPT | |
| SCHEMBL2578768 | 0.77 | TRPV1 (0.42) | GAATSHREGLN1SMN1; SMN2MAPT | |
| SCHEMBL2583662 | 0.76 | BCHE (0.47) | EPHX2 | |
| SCHEMBL2587147 | 0.76 | CRHBP (0.42) | TSHRSMN1; SMN2MEN1KMT2ALIPE | |
| SCHEMBL2582179 | 0.76 | RAB9A (0.47) | GAATSHRSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2584691 | 0.76 | ALDH1A1 (0.50) | GAASMN1; SMN2ALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |