Sugi Predict

Sugi Predict / Compounds / SCHEMBL2579126

SCHEMBL2579126

SCHEMBL2579126

NC(=S)Nc1ccc(F)c(C(F)(F)F)c1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ KIF11 P52732 1/20 0.51
▸ AR P10275 1/20 0.51
▸ GRM4 Q14833 1/20 0.50
▸ CDK8 P49336 1/20 0.45
▸ EPHX1 P07099 1/20 0.44
▸ KMT2A Q03164 2/20 0.43
▸ SLC22A12 Q96S37 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ KDR P35968 1/20 0.42
▸ ALDH1A1 P00352 2/20 0.42
▸ GAA P10253 1/20 0.42
▸ BLM P54132 1/20 0.42
▸ WRN Q14191 1/20 0.42
▸ LMNA P02545 1/20 0.42
▸ CYP1A2 P05177 1/20 0.42
▸ MEN1 O00255 1/20 0.42
▸ MAPT P10636 1/20 0.42
▸ HTT P42858 1/20 0.42
▸ NPSR1 Q6W5P4 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11591162 0.83 AR (0.51) ARGRM4CDK8EPHX1KMT2A
SCHEMBL20560572 0.83 GRM4 (0.54) ARGRM4CDK8EPHX1KMT2A
SCHEMBL31356647 0.83 AR (0.58) KIF11ARGRM4CDK8SLC22A12
SCHEMBL1380778 0.83 AR (0.58) KIF11ARGRM4CDK8SLC22A12
SCHEMBL13951457 0.81 KIF11 (0.50) KIF11EPHX1KMT2ASMN1; SMN2KDR
SCHEMBL3534970 0.81 KDR (0.66) KIF11GRM4KMT2ASMN1; SMN2KDR
SCHEMBL7570590 0.81 KMT2A (0.51) ARGRM4CDK8EPHX1KMT2A
SCHEMBL7169060 0.80 AR (0.56) ARGRM4CDK8SLC22A12KDR
SCHEMBL1933289 0.80 KMT2A (0.50) KIF11KMT2ASMN1; SMN2ALDH1A1GAA
SCHEMBL7570587 0.79 BRAF (0.55) ARGRM4CDK8EPHX1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1926719-B1 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 2017-05-31 — — EP disclosed
US-9388175-B2 2-aniline-4-aryl substituted thiazole derivatives JANSSEN PHARMACEUTICA N.V. (BE) 2016-07-12 — — US disclosed
EP-1418909-B1 2-AMINO-4, 5-TRISUBSTITUTED THIAzOLYL DERIVATIVES AND THEIR USE AGAINST AUTOIMMUNE DISEASES JANSSEN PHARMACEUTICA NV (BE) 2013-02-20 — — EP disclosed
CN-102863435-A 2-[[4-fluoro-3-(trifluoromethyl) phenyl] amino]-4-pyridyl-5-thiazole formaldehyde and preparation method of reduction product thereof YANCHENG INST TECHNOLOGY 2013-01-09 — — CN disclosed
US-20110269748-A1 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2011-11-03 — — US disclosed
CN-101263130-B 2-aniline-4-aryl substituted thiazole derivatives JANSSEN PHARMACEUTICA NV 2011-03-09 — — CN disclosed
US-7803823-B2 2-amino-4,5-trisubstituted thiazolyl derivatives JANSSEN PHARMACEUTICA NV (BE) 2010-09-28 — — US disclosed
CN-100496493-C 2-amino-4, 5-trisubstituted thiazolyl derivatives JANSSEN PHARMACEUTICA NV (BE) 2009-06-10 — — CN disclosed
CN-101263130-A 2-aniline-4-aryl substituted thiazole derivatives JANSSEN PHARMACEUTICA NV (BE) 2008-09-10 — — CN disclosed
EP-1926719-A2 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2008-06-04 — — EP disclosed
US-20070203189-A1 2-Amino-4,5-Trisubstituted Thiazolyl Derivatives LOVE CHRISTOPHER J 2007-08-30 — — US disclosed
US-7232838-B2 2-amino-4,5-trisubstituted thiazolyl derivatives JANSSEN PHARMACEUTICA N.V. (BE) 2007-06-19 — — US disclosed
WO-2007031440-A2 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2007-03-22 — — WO disclosed
US-20070010671-A1 Novel quinazoline derivatives and methods of treatment related to the use thereof ARENA PHARMACEUTICALS, INC. 2007-01-11 — — US disclosed
US-20040254191-A1 2-amino-4,5-trisubstituted thiazolyl derivatives JANSSEN PHARMACEUTICA N.V. (BE) 2004-12-16 — — US disclosed
CN-1541097-A 2-amino-4, 5-trisubstituted thiazolyl derivatives ղɭҩҵ���޹�˾ 2004-10-27 — — CN disclosed
EP-1418909-A2 2-AMINO-4, 5-TRISUBSTITUTED THIAOLYL DERIVATIVES AND THEIR USE AGAINST AUTOIMMUNE DISEASES JANSSEN PHARMACEUTICA N.V. (BE) 2004-05-19 — — EP disclosed
WO-2003015773-A2 2-AMINO-4,5-TRISUBSTITUTED THIAZOLYL DERIVATIVES AND THEIR USE AGAINST AUTOIMMUNE DISEASES JANSSEN PHARMACEUTICA N.V. (BE) 2003-02-27 — — WO disclosed
US-4713382-A N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrhythmic agents SYNTEX (U.S.A.) INC. (US) 1987-12-15 — — US disclosed
EP-0204265-A1 N-Phenyl-4-phenyl-1-piperazine carboxamidines and related compounds as antiarrhythmic agents LABORATOIRES SYNTEX S.A. (FR) 1986-12-10 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040254191-A1 2-amino-4,5-trisubstituted thiazolyl derivatives IL4I1, TLR1, NOD1 KIF11 3558/4885AR 1450/4885GRM4 1746/4885
US-20110269748-A1 2-ANILINE-4-ARYL SUBSTITUTED THIAZOLE DERIVATIVES CHRNA4, CHRNA5, CHRNA7 KIF11 4453/4885AR 2625/4885GRM4 217/4885
US-20070010671-A1 Novel quinazoline derivatives and methods of treatment related to the use thereof MCHR1, GPR119, MCHR2 KIF11 1709/4885AR 4115/4885GRM4 141/4885
US-20070203189-A1 2-Amino-4,5-Trisubstituted Thiazolyl Derivatives IFNG, IL15, IL5 KIF11 3455/4885AR 1810/4885GRM4 3296/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.