Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 8/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.34 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30489405 | 0.76 | OPRM1 (0.39) | USP30TP53BP1 | |
| SCHEMBL25807049 | 0.72 | SMYD3 (0.43) | CTSASMYD3ADORA1 | |
| SCHEMBL30112012 | 0.71 | GABRG2 (0.38) | USP30ACACB | |
| SCHEMBL19555968 | 0.71 | GABRG2 (0.38) | USP30ACACB | |
| SCHEMBL25797141 | 0.70 | DDR1 (0.49) | ABL1 | |
| SCHEMBL25804854 | 0.70 | LRRK2 (0.43) | SMYD3ADORA1 | |
| SCHEMBL31565272 | 0.69 | TNKS (0.54) | — | |
| SCHEMBL15752631 | 0.69 | LNPEP (0.37) | ACACBPROKR1CHRM4 | |
| SCHEMBL15710131 | 0.68 | AOC3 (0.37) | ACACBPROKR1CHRM4 | |
| SCHEMBL25804972 | 0.68 | KDR (0.36) | SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |