SCHEMBL25798906

SCHEMBL25798906

CSc1ccc(C#C[Si](C)(C)C)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACACB O00763 2/20 0.40
NOS3 P29474 2/20 0.36
NOS1 P29475 2/20 0.36
ALDH1A1 P00352 1/20 0.35
GABRA1 P14867 1/20 0.33
GABRG2 P18507 1/20 0.33
GABRB3 P28472 1/20 0.33
GABRA5 P31644 1/20 0.33
GABRA3 P34903 1/20 0.33
GABRA2 P47869 1/20 0.33
SLC6A4 P31645 3/20 0.32
PTGS2 P35354 1/20 0.32
NISCH Q9Y2I1 1/20 0.32
PLK1 P53350 1/20 0.31
MAOA P21397 1/20 0.31
SLC6A2 P23975 1/20 0.31
SLC6A3 Q01959 1/20 0.31
MAOB P27338 1/20 0.31
AOC3 Q16853 1/20 0.31
GRM5 P41594 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27134521 0.86 ACACB (0.36) ACACBNOS3NOS1GABRA1GABRG2
SCHEMBL1306384 0.83 GABRA1 (0.38) ALDH1A1GABRA1GABRG2GABRB3GABRA5
SCHEMBL10300058 0.81 ACACB (0.52) ACACBNOS3NOS1ALDH1A1SLC6A4
SCHEMBL20681670 0.81 ACACB (0.52) ACACBNOS3NOS1ALDH1A1SLC6A4
SCHEMBL1306505 0.81 APP (0.41) ALDH1A1GABRA1GABRG2GABRB3GABRA5
SCHEMBL24919969 0.79 MAOA (0.53) ALDH1A1GABRA1GABRG2GABRB3GABRA5
SCHEMBL4252316 0.78 KDM4E (0.38) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL29169050 0.78 SLC6A4 (0.38) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL27214767 0.77 ACACB (0.42) ACACBNOS3NOS1ALDH1A1SLC6A4
SCHEMBL2854252 0.77 CYP1A1 (0.44) GABRA1GABRG2GABRB3GABRA5GABRA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023027630-A9 A FLOW REACTOR, METHODS OF FABRICATION AND REACTIONS THEREOF NATIONAL UNIVERSITY OF SINGAPORE (SG) 2023-07-27 WO claimed
WO-2023027630-A2 A FLOW REACTOR, METHODS OF FABRICATION AND REACTIONS THEREOF NATIONAL UNIVERSITY OF SINGAPORE (SG) 2023-03-02 WO claimed
US-20250264649-A1 HIGH REFRACTIVE INDEX AND HIGHLY BIREFRINGENT SOLID ORGANIC MATERIALS META PLATFORMS TECH LLC (US) 2025-08-21 US disclosed
US-12320999-B2 High refractive index and highly birefringent solid organic materials META PLATFORMS TECHNOLOGIES, LLC (US) 2025-06-03 US disclosed
EP-4330736-A1 HIGH REFRACTIVE INDEX AND HIGHLY BIREFRINGENT SOLID ORGANIC MATERIALS META PLATFORMS TECHNOLOGIES, LLC (US) 2024-03-06 EP disclosed
CN-117203556-A High refractive index and high birefringence solid organic material 元平台技术有限公司 2023-12-08 CN disclosed
US-20230365543-A1 MATRIX METALLOPROTEINASE (MMP) INHIBITORS AND METHODS OF USE THEREOF FORESEE PHARMACEUTICALS USA, INC. 2023-11-16 US disclosed
WO-2023027630-A9 A FLOW REACTOR, METHODS OF FABRICATION AND REACTIONS THEREOF NATIONAL UNIVERSITY OF SINGAPORE (SG) 2023-07-27 WO disclosed
US-11673884-B2 Matrix metalloproteinase (MMP) inhibitors and methods of use thereof Foresee Pharmaceuticals Co., Inc. (TW) 2023-06-13 US disclosed
WO-2023027630-A2 A FLOW REACTOR, METHODS OF FABRICATION AND REACTIONS THEREOF NATIONAL UNIVERSITY OF SINGAPORE (SG) 2023-03-02 WO disclosed
WO-2022232071-A1 HIGH REFRACTIVE INDEX AND HIGHLY BIREFRINGENT SOLID ORGANIC MATERIALS META PLATFORMS TECHNOLOGIES, LLC (US) 2022-11-03 WO disclosed
US-20220342132-A1 HIGH REFRACTIVE INDEX AND HIGHLY BIREFRINGENT SOLID ORGANIC MATERIALS FACEBOOK TECHNOLOGIES, LLC 2022-10-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230365543-A1 MATRIX METALLOPROTEINASE (MMP) INHIBITORS AND METHODS OF USE THEREOF MMP12, MMP1, MMP11 ACACB 2116/4885NOS3 917/4885NOS1 798/4885
US-11673884-B2 Matrix metalloproteinase (MMP) inhibitors and methods of use thereof MMP12, MMP1, MMP11 ACACB 1997/4885NOS3 765/4885NOS1 518/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.