Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL102331 | 0.68 | PDPK1 (0.59) | PDPK1LOXL2CYP2A6SMPD3ADORA2A | |
| SCHEMBL1457635 | 0.67 | PDPK1 (0.39) | PDPK1LOXL2CYP2A6SMPD3ADORA2A | |
| SCHEMBL30534095 | 0.66 | PDPK1 (0.56) | PDPK1LOXL2CYP2A6SMPD3ADORA2A | |
| SCHEMBL30632310 | 0.66 | PDPK1 (0.56) | PDPK1LOXL2CYP2A6SMPD3ADORA2A | |
| SCHEMBL31556353 | 0.66 | PDPK1 (0.56) | PDPK1LOXL2CYP2A6SMPD3ADORA2A | |
| SCHEMBL2342778 | 0.65 | PDPK1 (0.47) | PDPK1LOXL2CYP2A6ADORA2AADORA1 | |
| SCHEMBL558212 | 0.65 | KDM4E (0.39) | CYP2A6ADORA2AADORA1ALDH1A1HSD17B10 | |
| SCHEMBL2733130 | 0.65 | PDPK1 (0.38) | PDPK1LOXL2CYP2A6SMPD3ADORA2A | |
| SCHEMBL4453199 | 0.65 | PDPK1 (0.42) | PDPK1LOXL2CYP2A6SMPD3ADORA2A | |
| SCHEMBL5759107 | 0.65 | CHRM2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069353-B1 | POLYCYCLIC AGENTS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS | BIOTA SCIENT MANAGEMENT (AU) | 2011-11-09 | — | — | EP | claimed |
| US-20090030038-A1 | Novel 8-Sulfonylamino-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5Ht6 Receptor | ASTRAZENECA AB (SE) | 2009-01-29 | — | — | US | claimed |
| EP-1888517-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006126939-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | claimed |
| EP-0913392-B1 | ETHYLENE DERIVATIVES AND PEST CONTROLLING AGENTS | NISSAN CHEMICAL IND LTD (JP) | 2003-07-02 | — | — | EP | claimed |
| US-4310619-A | LIGHT SENSITIVE ELEMENT COMPRISING A 5-PYRAZOLONE COUPLER | FUJI PHOTO FILM CO., LTD. (JP) | 1982-01-12 | — | — | US | claimed |
| US-20180042902-A1 | Heterocyclic Compounds and Uses Thereof | INTELLIKINE, LLC | 2018-02-15 | — | — | US | disclosed |
| EP-2225235-A2 | THIAZOLE CARBOXAMIDE DERIVATIVES AND THEIR USE TO TREAT CANCER | Schering Corporation (US) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009058729-A2 | THIAZOLE CARBOXAMIDE DERIVATIVES AND THEIR TO TREAT CANCER | SCHERING CORPORATION (US) | 2009-05-07 | — | — | WO | disclosed |
| US-20090030038-A1 | Novel 8-Sulfonylamino-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5Ht6 Receptor | ASTRAZENECA AB (SE) | 2009-01-29 | — | — | US | disclosed |
| CN-101228119-A | Novel 8-sulfonamido-3 amino substituted chroman or tetralin derivatives modulating the 5HT6 receptor | ASTRAZENECA AB (SE) | 2008-07-23 | — | — | CN | disclosed |
| US-20080095740-A1 | PIPERIDINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS | SCHERING CORPORATION | 2008-04-24 | — | — | US | disclosed |
| EP-1888517-A1 | NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| EP-1706388-A1 | THERAPEUTIC AGENTS II | AstraZeneca AB (SE) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005070902-A1 | THERAPEUTIC AGENTS II | ASTRAZENECA AB (SE) | 2005-08-04 | — | — | WO | disclosed |
| US-20040157834-A1 | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor | PFIZER INC | 2004-08-12 | — | — | US | disclosed |
| US-6720330-B2 | INCREASING SECRETION OF GROWTH HORMONE, GASTRIN, OR GLUCAGON IN A MAMMAL; INHIBITING THE BINDING OF SOMATOSTATIN TO AN SST2 RECEPTOR | PFIZER INC. | 2004-04-13 | — | — | US | disclosed |
| US-20020091090-A1 | Somatostatin antagonists and agonists | COLE BRIDGET M (US) | 2002-07-11 | — | — | US | disclosed |
| US-20020091125-A1 | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor | HAY BRUCE A (US) | 2002-07-11 | — | — | US | disclosed |
| US-5866616-A | 3,3-(disubstituted) cyclohexan-1-ol monomers and related compounds | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030038-A1 | Novel 8-Sulfonylamino-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5Ht6 Receptor | HTR6, HTR1A, HTR1D | PDPK1 4236/4885LOXL2 4451/4885CYP2A6 172/4885 |
| US-20020091090-A1 | Somatostatin antagonists and agonists | GHSR, GHRHR, SSTR3 | PDPK1 3573/4885LOXL2 4227/4885CYP2A6 535/4885 |
| US-20180042902-A1 | Heterocyclic Compounds and Uses Thereof | PIK3CA, PIK3CD, PIK3CB | PDPK1 12/4885LOXL2 1951/4885CYP2A6 2417/4885 |
| US-20080095740-A1 | PIPERIDINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS | CCR5, CXCR3, CCR1 | PDPK1 3315/4885LOXL2 3434/4885CYP2A6 1389/4885 |
| US-20040157834-A1 | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor | SSTR2, GHSR, SSTR1 | PDPK1 4343/4885LOXL2 3186/4885CYP2A6 558/4885 |
| US-20020091125-A1 | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor | SSTR2, GHSR, SSTR1 | PDPK1 4235/4885LOXL2 3246/4885CYP2A6 568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.