Sugi Predict

Sugi Predict / Compounds / SCHEMBL2582528

SCHEMBL2582528

SCHEMBL2582528

O=C(Nc1ccc(N2CCNCC2)cc1)c1ccccc1-c1ccc(C(F)(F)F)cc1

nearest known ligand 0.64

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ MAPKAPK2 P49137 3/20 0.64
▸ KDM4E B2RXH2 2/20 0.54
▸ GAA P10253 2/20 0.54
▸ ALDH1A1 P00352 2/20 0.54
▸ MAPT P10636 2/20 0.54
▸ LMNA P02545 1/20 0.54
▸ MTTP P55157 6/20 0.52
▸ APOB P04114 5/20 0.52
▸ MT-CO2 P00403 1/20 0.51
▸ SMN1; SMN2 Q16637 3/20 0.51
▸ NPY2R P49146 1/20 0.49
▸ NPC1 O15118 1/20 0.49
▸ TP53 P04637 1/20 0.49
▸ RAB9A P51151 1/20 0.49
▸ MCL1 Q07820 1/20 0.49
▸ PTGS1 P23219 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2582475 0.88 CHRNB2 (0.61) MAPKAPK2GAAALDH1A1MAPTLMNA
SCHEMBL7137919 0.85 MAPT (0.56) MAPKAPK2KDM4EGAAALDH1A1MAPT
SCHEMBL14511122 0.85 NOTUM (0.54) KDM4EGAAALDH1A1MAPTLMNA
SCHEMBL6698014 0.84 CA1 (0.52) KDM4EGAAALDH1A1MAPTLMNA
SCHEMBL2588205 0.83 HIF1A (0.64) KDM4EGAAALDH1A1MAPTLMNA
SCHEMBL12082732 0.82 NPY2R (0.54) KDM4EGAAALDH1A1MAPTLMNA
SCHEMBL14511118 0.82 MTTP (0.52) KDM4EGAAALDH1A1MAPTLMNA
SCHEMBL12082647 0.82 MTTP (0.50) KDM4EGAAALDH1A1MAPTLMNA
SCHEMBL5153696 0.82 APOB (0.52) KDM4EGAAALDH1A1MAPTLMNA
SCHEMBL6698710 0.81 MAPT (0.56) KDM4EGAAALDH1A1MAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160081997-A1 PIPERIDINE/PIPERAZINE DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 2016-03-24 — — US disclosed
US-20160081997-A1 PIPERIDINE/PIPERAZINE DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 2016-03-24 — — US disclosed
US-9227935-B2 Piperidine/piperazine derivatives JANSSEN PHARMACEUTICAL N.V. (BE) 2016-01-05 — — US disclosed
US-9227935-B2 Piperidine/piperazine derivatives JANSSEN PHARMACEUTICAL N.V. (BE) 2016-01-05 — — US disclosed
US-20150087629-A1 PIPERIDINE/PIPERAZINE DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 2015-03-26 — — US disclosed
US-20150087629-A1 PIPERIDINE/PIPERAZINE DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 2015-03-26 — — US disclosed
US-8946228-B2 Piperidine/piperazine derivatives JANSSEN PHARMACEUTICA N.V. (BE) 2015-02-03 — — US disclosed
US-8946228-B2 Piperidine/piperazine derivatives JANSSEN PHARMACEUTICA N.V. (BE) 2015-02-03 — — US disclosed
US-8354402-B2 Polyarylcarboxamides useful as lipid lowering agents JANSSEN PHARMACEUTICA N.V. (BE) 2013-01-15 — — US disclosed
US-20110269747-A1 POLYARYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS MEERPOEL LIEVEN 2011-11-03 — — US disclosed
EP-1806341-A2 (+)Phenyl-(4-{4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-acetic acid methyl ester as lipid lowering agent JANSSEN PHARMACEUTICA N.V. (BE) 2007-07-11 — — EP disclosed
US-20070082888-A1 POLYARYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS MEERPOEL LIEVEN 2007-04-12 — — US disclosed
US-7169796-B2 Polyarylcarboxamides useful as lipid lowering agents JANSSEN PHARMACEUTICA N.V. (BE) 2007-01-30 — — US disclosed
EP-1379515-B1 LIPID LOWERING BIPHENYLCARBOXAMIDES JANSSEN PHARMACEUTICA NV (BE) 2006-12-27 — — EP disclosed
US-20060241113-A1 Polyarylcarboxamides useful as lipid lowering agents MEERPOEL LIEVEN 2006-10-26 — — US disclosed
US-20050159402-A1 Polyarylcarboxamides useful as lipid lowering agents MEERPOEL LIEVEN (BE) 2005-07-21 — — US disclosed
US-6878724-B2 Polyarylcarboxamides useful as lipid lowering agents JANSSEN-PHARMACEUTICA N.V. (BE) 2005-04-12 — — US disclosed
US-20040014971-A1 Polyarylcarboxamides useful as lipid lowering agents JANSSEN PHARMACEUTICA N.V. (BE) 2004-01-22 — — US disclosed
EP-1379515-A1 LIPID LOWERING BIPHENYLCARBOXAMIDES JANSSEN PHARMACEUTICA N.V. (BE) 2004-01-14 — — EP disclosed
WO-2002081460-A1 LIPID LOWERING BIPHENYLCARBOXAMIDES JANSSEN PHARMACEUTICA N.V. (BE) 2002-10-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050159402-A1 Polyarylcarboxamides useful as lipid lowering agents LIPC, PNLIP, APOB MAPKAPK2 3750/4885KDM4E 2602/4885GAA 476/4885
US-20060241113-A1 Polyarylcarboxamides useful as lipid lowering agents LIPC, PNLIP, APOB MAPKAPK2 3750/4885KDM4E 2602/4885GAA 476/4885
US-20110269747-A1 POLYARYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS LIPC, PNLIP, APOB MAPKAPK2 3750/4885KDM4E 2602/4885GAA 476/4885
US-20150087629-A1 PIPERIDINE/PIPERAZINE DERIVATIVES DGAT1, NAT1, SOAT1 MAPKAPK2 2057/4885KDM4E 3538/4885GAA 3165/4885
US-20040014971-A1 Polyarylcarboxamides useful as lipid lowering agents SREBF1, LIPC, CPT1A MAPKAPK2 3913/4885KDM4E 2792/4885GAA 769/4885
US-20070082888-A1 POLYARYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS LIPC, PNLIP, APOB MAPKAPK2 3750/4885KDM4E 2602/4885GAA 476/4885
US-20160081997-A1 PIPERIDINE/PIPERAZINE DERIVATIVES DGAT1, DGAT2, SOAT1 MAPKAPK2 1855/4885KDM4E 3529/4885GAA 3263/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.