SCHEMBL25825833

SCHEMBL25825833

Oc1cccc2c1CC1(CNC1)C2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.41
BAD Q92934 1/20 0.41
HTR1A P08908 1/20 0.39
HTR1B P28222 1/20 0.39
HTR2A P28223 1/20 0.39
HTR2C P28335 1/20 0.39
HTR7 P34969 1/20 0.39
HTR6 P50406 1/20 0.39
DRD2 P14416 2/20 0.39
DRD3 P35462 2/20 0.39
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
CA4 P22748 2/20 0.35
CA6 P23280 2/20 0.35
CHRNB2 P17787 1/20 0.35
CHRNA4 P43681 1/20 0.35
DRD1 P21728 1/20 0.33
DRD5 P21918 1/20 0.33
PARP1 P09874 1/20 0.33
PNMT P11086 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30568091 0.82 HTR1A (0.40) BCL2L1BADHTR1AHTR1BHTR2A
SCHEMBL11704797 0.78 BCL2L1 (0.46) BCL2L1BADHTR1AHTR1BHTR2A
SCHEMBL24482375 0.78 ADRA2A (0.41) DRD2DRD3CHRNB2CHRNA4
SCHEMBL21788503 0.75 HTR2C (0.40) HTR2AHTR2CDRD2PNMT
SCHEMBL29610357 0.75 HTR2C (0.40) HTR2AHTR2CDRD2PNMT
SCHEMBL12804798 0.71 BCL2L1 (0.45) BCL2L1BADHTR1AHTR1BHTR2A
SCHEMBL2051877 0.71 BCL2L1 (0.45) BCL2L1BADHTR1AHTR1BHTR2A
SCHEMBL25825832 0.68 SIGMAR1 (0.46)
SCHEMBL25825834 0.67 SPR (0.38) BCL2L1BADHTR1AHTR1BHTR2A
SCHEMBL150017 0.66

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023125944-A1 COMPOUND CONTAINING HETEROCYCLIC RING 正大天晴药业集团股份有限公司 2023-07-06 WO disclosed