Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | GSTK1 | Q9Y2Q3 | 2/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2581324 | 0.95 | EPHX2 (0.48) | KDM4EEPHX2GSTK1ENPEPPRMT1 | |
| SCHEMBL3276636 | 0.94 | EPHX2 (0.47) | KDM4EEPHX2GSTK1PRMT1HDAC3 | |
| SCHEMBL3337710 | 0.94 | EPHX2 (0.47) | KDM4EEPHX2GSTK1PRMT1HDAC3 | |
| SCHEMBL2575373 | 0.92 | FAAH (0.42) | EPHX2GSTK1FOLH1ENPEPHDAC3 | |
| SCHEMBL15195616 | 0.85 | DNM1 (0.40) | EPHX2GSTK1FOLH1ENPEPHDAC3 | |
| SCHEMBL3276879 | 0.85 | HDAC3 (0.36) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Zinc Ion SCHEMBL3337795 | 0.85 | HDAC3 (0.36) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Dihydrolipoic Acid SCHEMBL867951 | 0.85 | FOLH1 (0.56) | GSTK1FOLH1ENPEPLMNATSHR | |
| Dihydrolipoic Acid SCHEMBL618576 | 0.85 | FOLH1 (0.56) | GSTK1FOLH1ENPEPLMNATSHR | |
| Dihydrolipoic Acid SCHEMBL1115003 | 0.85 | FOLH1 (0.56) | GSTK1FOLH1ENPEPLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100367949-C | Melanin extinguisher | OGA RES INC (JP) | 2008-02-13 | — | — | CN | claimed |
| US-20060122100-A1 | Melanin extinguisher | OGA RESEARCH, INCORPORATED (JP) | 2006-06-08 | — | — | US | claimed |
| CN-1681490-A | Melanin extinguisher | OGA RES INC (JP) | 2005-10-12 | — | — | CN | claimed |
| EP-1547590-A1 | MELANIN EXTINGUISHER | Oga Research, Incorporated (JP) | 2005-06-29 | — | — | EP | claimed |
| US-20040092586-A1 | Novel a-lipoic acid derivative and use thereof | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2004-05-13 | — | — | US | claimed |
| EP-1371640-A1 | NOVEL A-LIPOIC ACID DERIVATIVE AND USE THEREOF | Senju Pharmaceutical Co., Ltd. (JP) | 2003-12-17 | — | — | EP | claimed |
| US-8048911-B2 | Melanin eliminator preparation | OGA Research, Inc. (JP) | 2011-11-01 | — | — | US | disclosed |
| US-20100152288-A1 | NOVEL a-LIPOIC ACID DERIVATIVES AND APPLICATIONS THEREOF | SENJU PHARMACEUTICAL CO. LTD. (JP) | 2010-06-17 | — | — | US | disclosed |
| US-7700080-B2 | Method of suppressing melanin production by metal chelates of lipoyl amino acid derivatives | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2010-04-20 | — | — | US | disclosed |
| EP-1371640-B1 | NOVEL A-LIPOIC ACID DERIVATIVE AND USE THEREOF | SENJU PHARMA CO (JP) | 2009-10-28 | — | — | EP | disclosed |
| US-20090093541-A1 | MELANIN ELIMINATOR PREPARATION | OGA RESEARCH, INC (JP) | 2009-04-09 | — | — | US | disclosed |
| CN-100367949-C | Melanin extinguisher | OGA RES INC (JP) | 2008-02-13 | — | — | CN | disclosed |
| US-20060122100-A1 | Melanin extinguisher | OGA RESEARCH, INCORPORATED (JP) | 2006-06-08 | — | — | US | disclosed |
| CN-1681490-A | Melanin extinguisher | OGA RES INC (JP) | 2005-10-12 | — | — | CN | disclosed |
| EP-1547590-A1 | MELANIN EXTINGUISHER | Oga Research, Incorporated (JP) | 2005-06-29 | — | — | EP | disclosed |
| US-20040092586-A1 | Novel a-lipoic acid derivative and use thereof | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2004-05-13 | — | — | US | disclosed |
| EP-1371640-A1 | NOVEL A-LIPOIC ACID DERIVATIVE AND USE THEREOF | Senju Pharmaceutical Co., Ltd. (JP) | 2003-12-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122100-A1 | Melanin extinguisher | TYR, MC1R, MITF | KDM4E 2477/4885EPHX2 4410/4885GSTK1 2911/4885 |
| US-20100152288-A1 | NOVEL a-LIPOIC ACID DERIVATIVES AND APPLICATIONS THEREOF | TYR, SERPINB1, LPO | KDM4E 4183/4885EPHX2 1159/4885GSTK1 486/4885 |
| US-20090093541-A1 | MELANIN ELIMINATOR PREPARATION | TYR, MC1R, MCHR1 | KDM4E 1751/4885EPHX2 3181/4885GSTK1 3045/4885 |
| US-20040092586-A1 | Novel a-lipoic acid derivative and use thereof | TYR, SERPINB1, LPO | KDM4E 3949/4885EPHX2 1812/4885GSTK1 860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.