Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.37 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3690645 | 0.81 | PTGS2 (0.34) | PTGS2PTGS1CYP2C9NPC1RAB9A | |
| SCHEMBL2587536 | 0.78 | MEN1 (0.37) | — | |
| SCHEMBL946905 | 0.67 | KMT2A (0.45) | PTGS2PTGS1CYP2C9NPC1RAB9A | |
| SCHEMBL878079 | 0.67 | MAPT (0.37) | PTGS2 | |
| SCHEMBL877521 | 0.67 | CRBN (0.35) | PTGS2PTGS1CYP2C9NPC1RAB9A | |
| SCHEMBL26337591 | 0.66 | PTGS2 (0.40) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL757069 | 0.65 | RAB9A (0.47) | PTGS2PTGS1CYP2C9NPC1RAB9A | |
| SCHEMBL21720871 | 0.65 | PTGS2 (0.37) | PTGS2PTGS1RXRANR1H2NR1H3 | |
| SCHEMBL21768447 | 0.65 | PTGS2 (0.39) | PTGS2PTGS1CYP2C9NPC1RAB9A | |
| SCHEMBL30295506 | 0.65 | MEN1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647731-B2 | Thiazolopyrimidinones and methods of use thereof | GENENTECH, INC. (US) | 2020-05-12 | — | — | US | disclosed |
| US-10647731-B2 | Thiazolopyrimidinones and methods of use thereof | GENENTECH, INC. (US) | 2020-05-12 | — | — | US | disclosed |
| EP-2967073-B9 | LXR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2019-04-10 | — | — | EP | disclosed |
| EP-2967073-B9 | LXR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2019-04-10 | — | — | EP | disclosed |
| EP-3239137-B1 | (5R)-4,5-DIHYDRO-ISOXAZOLE DERIVATIVES AS WELL AS 1-(2-CHLOROACETYL)-4-PIPERIDINE-CARBONITRILE AND -CARBOXAMIDE DERIVATIVES AS INTERMEDIATES IN THE PREPARATION OF E.G. 4-[4-[(5R)-4,5-DIHYDRO-ISOXAZOL-3-YL]-THIAZOL-2-YL]-PIPERIDINE DERIVATIVES AS FUNGICIDES FOR CROP PROTECTION | DU PONT (US) | 2019-02-13 | — | — | EP | disclosed |
| EP-3415519-A1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | F. Hoffmann-La Roche AG (CH) | 2018-12-19 | — | — | EP | disclosed |
| US-20180244694-A1 | THIAZOLOPYRIMIDINONES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-08-30 | — | — | US | disclosed |
| EP-2967073-B1 | LXR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-08-01 | — | — | EP | disclosed |
| EP-2967073-B1 | LXR MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-08-01 | — | — | EP | disclosed |
| EP-3055315-B1 | THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY | HOFFMANN LA ROCHE (CH) | 2018-07-25 | — | — | EP | disclosed |
| WO-2014152738-A1 | LXR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-09-25 | — | — | WO | disclosed |
| US-20140081027-A1 | FUNGICIDAL AZOCYCLIC AMIDES | E I DU PONT DE NEMOURS AND COMPANY (US) | 2014-03-20 | — | — | US | disclosed |
| US-8642634-B2 | Fungicidal azocyclic amides | E I DU PONT DE NEMOURS AND COMPANY (US) | 2014-02-04 | — | — | US | disclosed |
| US-8586611-B2 | Fungicidal carboxamides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2013-11-19 | — | — | US | disclosed |
| EP-1948649-B1 | FUNGICIDAL CARBOXAMIDES | DU PONT (US) | 2013-06-26 | — | — | EP | disclosed |
| US-8449898-B2 | Fungicidal mixtures | E I DU PONT DE NEMOURS AND COMPANY (US) | 2013-05-28 | — | — | US | disclosed |
| US-20110269712-A1 | Fungicidal Carboxamides | BISAHA JOHN JOSEPH | 2011-11-03 | — | — | US | disclosed |
| US-20100240619-A1 | FUNGICIDAL MIXTURES | CORTEVA AGRISCIENCE LLC | 2010-09-23 | — | — | US | disclosed |
| US-20090156592-A1 | Fungicidal Azocyclic Amides | E.I. DU PONT DE NEMOURS AND COMPANY (DE) | 2009-06-18 | — | — | US | disclosed |
| WO-2008091594-A2 | FUNGICIDAL MIXTURES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269712-A1 | Fungicidal Carboxamides | NAT1, PFAS, CHRM1 | PTGS2 1611/4885PTGS1 1152/4885RXRA 2245/4885 |
| US-10647731-B2 | Thiazolopyrimidinones and methods of use thereof | TPMT, THPO, CYP11B2 | PTGS2 919/4885PTGS1 1329/4885RXRA 1562/4885 |
| US-20140081027-A1 | FUNGICIDAL AZOCYCLIC AMIDES | ARG1, NAT1, CHRM1 | PTGS2 2833/4885PTGS1 2251/4885RXRA 817/4885 |
| US-20100240619-A1 | FUNGICIDAL MIXTURES | CYP1B1, CYP1A1, NOX1 | PTGS2 3083/4885PTGS1 1901/4885RXRA 1783/4885 |
| US-20180244694-A1 | THIAZOLOPYRIMIDINONES AND METHODS OF USE THEREOF | TPMT, THPO, CYP11B2 | PTGS2 919/4885PTGS1 1329/4885RXRA 1562/4885 |
| US-20090156592-A1 | Fungicidal Azocyclic Amides | ARG1, NAT1, CHRM1 | PTGS2 2833/4885PTGS1 2251/4885RXRA 817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.