Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7930838 | 0.89 | ALDH1A1 (0.43) | HSD11B1KMT2AALDH1A1CA1CA2 | |
| SCHEMBL3493018 | 0.88 | HSD11B1 (0.46) | HSD11B1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6643810 | 0.85 | HSP90AA1 (0.43) | ALDH1A1SMN1; SMN2LMNAMAPTHTT | |
| SCHEMBL3494530 | 0.84 | HSD11B1 (0.45) | HSD11B1KMT2ASMN1; SMN2MAPTCYP2C9 | |
| SCHEMBL3303470 | 0.83 | KDM4E (0.43) | KMT2AALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL14270838 | 0.81 | HSD11B1 (0.45) | HSD11B1ALDH1A1SMN1; SMN2HTTKDM4E | |
| SCHEMBL17888631 | 0.80 | HSD11B1 (0.45) | HSD11B1ALDH1A1MAPT | |
| SCHEMBL7922665 | 0.80 | CSNK2A1 (0.46) | HSD11B1KMT2AALDH1A1CA1CA2 | |
| SCHEMBL13713243 | 0.80 | SMN1; SMN2 (0.48) | HSD11B1KMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6942043 | 0.79 | CA1 (0.44) | KMT2AALDH1A1SMN1; SMN2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827664-B2 | Biaryl amides with modified sugar groups for treatment of diseases associated with heat shock protein pathway | REATA PHARMACEUTICALS, INC (US) | 2023-11-28 | — | — | US | disclosed |
| US-11702418-B2 | SOS1 inhibitors | Mirati Therapeutics, Inc. (US) | 2023-07-18 | — | — | US | disclosed |
| US-20230137886-A1 | SOS1 INHIBITORS | Mirati Therapeutics, Inc. | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230137886-A1 | SOS1 INHIBITORS | SOS1, SOS2, SAV1 | HSD11B1 1051/4885KMT2A 3283/4885ALDH1A1 3260/4885 |
| US-11702418-B2 | SOS1 inhibitors | SOS1, SOS2, SOST | HSD11B1 1028/4885KMT2A 3302/4885ALDH1A1 3367/4885 |
| US-11827664-B2 | Biaryl amides with modified sugar groups for treatment of diseases associated with heat shock protein pathway | HSPA2, HSP90AB2P, HSF1 | HSD11B1 3189/4885KMT2A 4576/4885ALDH1A1 1233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.