Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592540 | 0.83 | KCNA5 (0.55) | KDM4EKMT2AKCNA5NFE2L2MAPT | |
| SCHEMBL2593202 | 0.82 | SMN1; SMN2 (0.51) | KMT2AALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL775777 | 0.82 | TAAR1 (0.50) | KMT2AALDH1A1SMN1; SMN2MEN1L3MBTL1 | |
| SCHEMBL9600152 | 0.80 | KMT2A (0.50) | KMT2AALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL4212164 | 0.78 | KDM4E (0.61) | KDM4EKMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1272066 | 0.74 | L3MBTL1 (0.45) | KDM4EKMT2AKCNA5ALDH1A1MAPT | |
| SCHEMBL776330 | 0.74 | TAAR1 (0.46) | KMT2AALDH1A1MAPTMEN1HSD17B10 | |
| Formic Acid SCHEMBL28118279 | 0.73 | KDM4E (0.57) | KDM4EKMT2ANFE2L2ALDH1A1MAPT | |
| SCHEMBL2589313 | 0.73 | KDM4E (0.56) | KDM4EKMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7400760 | 0.73 | KDM4E (0.56) | KDM4EKMT2AALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |