Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9600152 | 0.90 | KMT2A (0.50) | SMN1; SMN2KMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL2592540 | 0.86 | KCNA5 (0.55) | SMN1; SMN2KMT2ACYP3A4MAPT | |
| SCHEMBL2585047 | 0.82 | KDM4E (0.53) | SMN1; SMN2KMT2AMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL8361647 | 0.81 | LMNA (0.49) | SMN1; SMN2KMT2ALMNAL3MBTL1ALDH1A1 | |
| SCHEMBL88641 | 0.79 | CA2 (0.64) | SMN1; SMN2KMT2ALMNAFAAHPRSS1 | |
| SCHEMBL28641442 | 0.79 | HRH1 (0.52) | SMN1; SMN2KMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL1272066 | 0.79 | L3MBTL1 (0.45) | SMN1; SMN2KMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL5432527 | 0.79 | TDP1 (0.47) | SMN1; SMN2KMT2ALMNACYP3A4MAPT | |
| Phenylmethanesulfonic Acid SCHEMBL6115229 | 0.77 | TDP1 (0.50) | SMN1; SMN2KMT2ALMNACYP3A4MAPT | |
| SCHEMBL28332352 | 0.77 | CA2 (0.61) | SMN1; SMN2KMT2ALMNAFAAHPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |