Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2593202 | 0.86 | SMN1; SMN2 (0.51) | MAPTSMN1; SMN2CYP3A4KMT2A | |
| SCHEMBL9600152 | 0.84 | KMT2A (0.50) | MAPTSMN1; SMN2PKMKMT2A | |
| SCHEMBL2585047 | 0.83 | KDM4E (0.53) | KCNA5RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL4635552 | 0.79 | KDM4E (0.56) | KCNA5RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL422010 | 0.78 | USP2 (0.51) | MAPTKMT2A | |
| SCHEMBL1272066 | 0.78 | L3MBTL1 (0.45) | KCNA5RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL3233668 | 0.75 | L3MBTL1 (0.65) | KCNA5RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL8361647 | 0.75 | LMNA (0.49) | RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL8867729 | 0.74 | CYP1A2 (0.56) | KCNA5RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL28641442 | 0.74 | HRH1 (0.52) | MAPTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |