Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | FSHR | P23945 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4549856 | 0.99 | ALDH1A1 (0.39) | ALDH1A1CTSLCTSBCTSSTSHR | |
| SCHEMBL21967075 | 0.83 | KMT2A (0.34) | P2RX7MEN1KMT2ALMNA | |
| SCHEMBL21967065 | 0.82 | MEN1 (0.34) | P2RX7MEN1KMT2ALMNA | |
| SCHEMBL2724465 | 0.81 | STK17B (0.47) | P2RX7MEN1KMT2AMAPKAPK2 | |
| SCHEMBL25857100 | 0.80 | CTSS (0.38) | ALDH1A1CTSLCTSBCTSSTSHR | |
| SCHEMBL2726118 | 0.80 | STK17B (0.48) | P2RX7MEN1KMT2AMAPKAPK2 | |
| SCHEMBL15249204 | 0.79 | CTSS (0.36) | ALDH1A1CTSLCTSBCTSSTSHR | |
| SCHEMBL1284434 | 0.77 | SIRT5 (0.50) | P2RX7LMNASMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL16057286 | 0.77 | HTT (0.50) | LMNASMN1; SMN2HTTL3MBTL1KEAP1 | |
| SCHEMBL5149463 | 0.76 | TGM2 (0.50) | LMNASMN1; SMN2HTTL3MBTL1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11708337-B2 | Synthesis of 1,4-diazaspiro[5.5]undecan-3-one | G1 THERAPEUTICS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11708337-B2 | Synthesis of 1,4-diazaspiro[5.5]undecan-3-one | NDC1, SDC1, SDC2 | ALDH1A1 723/4885CTSL 2364/4885CTSB 3921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.