SCHEMBL2586280

SCHEMBL2586280

COc1cc(C(=O)O)n(-c2ncccc2Cl)n1

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 6/20 0.40
RBP4 P02753 1/20 0.40
DHODH Q02127 1/20 0.38
TRPA1 O75762 3/20 0.37
MYC P01106 1/20 0.36
SLC16A3 O15427 1/20 0.36
SLC16A1 P53985 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluoride SCHEMBL27807875 0.99 MALT1 (0.39) MALT1RBP4DHODHTRPA1MYC
SCHEMBL14698527 0.90 MALT1 (0.40) MALT1RBP4DHODHTRPA1
SCHEMBL16014505 0.88 NPC1 (0.40) TRPA1SLC16A3SLC16A1
SCHEMBL16014575 0.86 ALDH1A1 (0.39) MALT1TRPA1SLC16A3SLC16A1
SCHEMBL30234432 0.84 SMN1; SMN2 (0.49)
SCHEMBL25702840 0.84 SMN1; SMN2 (0.49)
SCHEMBL16014740 0.84 NPC1 (0.37) MALT1TRPA1
SCHEMBL3177562 0.83 HIF1A (0.34) MALT1TRPA1SLC16A3SLC16A1
SCHEMBL950148 0.83 ALDH1A1 (0.43) MALT1DHODHMYC
SCHEMBL535475 0.83 DHODH (0.41) MALT1DHODHTRPA1MYC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3728256-B1 PYRAZOLOPYRIDINE-DIAMIDES, THEIR USE AS INSECTICIDE AND PROCESSES FOR PREPARING THE SAME PI INDUSTRIES LTD (IN) 2024-10-02 EP disclosed
US-20240308988-A1 Method For Controlling Diamide Resistant Pests and Compounds Therefor SYNGENTA CROP PROTECTION AG (CH) 2024-09-19 US disclosed
US-12024510-B2 Pyrazolopyridine-diamides, their use as insecticide and processes for preparing the same PI INDUSTRIES LTD. (IN) 2024-07-02 US disclosed
EP-4380363-A1 METHOD FOR CONTROLLING DIAMIDE RESISTANT PESTS & COMPOUNDS THEREFOR Syngenta Crop Protection AG (CH) 2024-06-12 EP disclosed
EP-4376616-A1 METHOD FOR CONTROLLING DIAMIDE RESISTANT PESTS & COMPOUNDS THEREFOR Syngenta Crop Protection AG (CH) 2024-06-05 EP disclosed
CN-118076228-A Methods for controlling diamide-resistant pests and compounds thereof 先正达农作物保护股份公司 2024-05-24 CN disclosed
CN-117813006-A Methods for controlling diamide-resistant pests and compounds thereof 先正达农作物保护股份公司 2024-04-02 CN disclosed
CN-117715523-A Methods for controlling diamide-resistant pests and compounds thereof 先正达农作物保护股份公司 2024-03-15 CN disclosed
CN-111670186-B Pyrazolopyridine-diamides, their use as pesticides and process for their preparation PI工业有限公司 2023-10-17 CN disclosed
WO-2023110710-A1 METHOD FOR CONTROLLING DIAMIDE RESISTANT PESTS & COMPOUNDS THEREFOR SYNGENTA CROP PROTECTION AG (CH) 2023-06-22 WO disclosed
US-8658801-B2 Pesticides containing a bicyclic bisamide structure SYNGENTA CROP PROTECTION, LLC (US) 2014-02-25 US disclosed
US-8598078-B2 Condensed anthran I lami de derivatives as insecticides SYNGENTA CROP PROTECTION, LLC (US) 2013-12-03 US disclosed
EP-2178859-B1 CONDENSED ANTHRANILAMIDE DERIVATIVES AS INSECTISIDES SYNGENTA PARTICIPATIONS AG (CH) 2011-12-21 EP disclosed
US-20110271406-A1 CONDENSED ANTHRAN I LAMI DE DERIVATIVES AS INSECTICIDES SYNGENTA CROP PROTECTION, INC. (US) 2011-11-03 US disclosed
EP-2178859-A2 CONDENSED ANTHRANILAMIDE DERIVATIVES AS INSECTISIDES Syngenta Participations AG (CH) 2010-04-28 EP disclosed
US-20090298816-A1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE SYNGENTA CROP PROTECTION, INC. (US) 2009-12-03 US disclosed
EP-1984354-B1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE SYNGENTA PARTICIPATIONS AG (CH) 2009-08-05 EP disclosed
WO-2009024341-A2 CONDENSED ANTHRAN I LAMI DE DERIVATIVES AS INSECTISIDES SYNGENTA PARTICIPATIONS AG, (CH) 2009-02-26 WO disclosed
EP-1984354-A1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE Syngeta Participations AG (CH) 2008-10-29 EP disclosed
WO-2007093402-A1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE SYNGENTA PARTICIPATIONS AG (CH) 2007-08-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240308988-A1 Method For Controlling Diamide Resistant Pests and Compounds Therefor DDT, NOS1, SLC11A2 MALT1 2427/4885RBP4 4146/4885DHODH 90/4885
US-20090298816-A1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE DDT, ACHE, GAP43 MALT1 2347/4885RBP4 3387/4885DHODH 786/4885
US-12024510-B2 Pyrazolopyridine-diamides, their use as insecticide and processes for preparing the same DDT, QDPR, CYP1A1 MALT1 4530/4885RBP4 3986/4885DHODH 93/4885
US-20110271406-A1 CONDENSED ANTHRAN I LAMI DE DERIVATIVES AS INSECTICIDES ECI1, FURIN, DDT MALT1 2156/4885RBP4 3870/4885DHODH 224/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.