Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 8/20 | 0.90 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.90 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CHKA | P35790 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL900260 | 0.95 | NCF1 (1.00) | NCF1ADRB2ADRB1PKMALOX15 | |
| SCHEMBL2918624 | 0.85 | NCF1 (0.81) | NCF1ADRB2ADRB1MAPTHTR6 | |
| SCHEMBL2594228 | 0.81 | NCF1 (0.90) | NCF1ADRB2PKMALOX15CASP1 | |
| SCHEMBL6125225 | 0.80 | ADRB2 (0.72) | NCF1ADRB2PKMALOX15CASP1 | |
| SCHEMBL23412205 | 0.78 | NCF1 (0.88) | NCF1ADRB2ADRB1PKMALOX15 | |
| SCHEMBL30059007 | 0.78 | NCF1 (0.70) | NCF1ADRB2PKMALOX15CASP1 | |
| SCHEMBL5638528 | 0.78 | NCF1 (0.70) | NCF1ADRB2PKMALOX15CASP1 | |
| SCHEMBL13153253 | 0.78 | ADRB2 (0.69) | NCF1ADRB2PKMALOX15CASP1 | |
| SCHEMBL25656138 | 0.77 | NCF1 (0.62) | NCF1ADRB2ADRB1PKMALOX15 | |
| SCHEMBL18386565 | 0.77 | ADRB2 (0.67) | NCF1ADRB2PKMALOX15CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9085557-B2 | Quinolylpiperazino substituted thiolactone compounds and process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-07-21 | — | — | US | claimed |
| EP-2566863-B1 | QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2014-05-14 | — | — | EP | claimed |
| US-20130190489-A1 | QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2013-07-25 | — | — | US | claimed |
| EP-2566863-A1 | QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF | Council of Scientific and Industrial Research (IN) | 2013-03-13 | — | — | EP | claimed |
| US-9085557-B2 | Quinolylpiperazino substituted thiolactone compounds and process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-07-21 | — | — | US | disclosed |
| EP-2566863-B1 | QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2014-05-14 | — | — | EP | disclosed |
| US-20130190489-A1 | QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2013-07-25 | — | — | US | disclosed |
| EP-2566863-A1 | QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF | Council of Scientific and Industrial Research (IN) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011138666-A1 | QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2011-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190489-A1 | QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF | SQOR, TST, FDPS | NCF1 3136/4885ADRB2 2221/4885ADRB1 1492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.