SCHEMBL258789

SCHEMBL258789

O=C(Cl)OC(c1ccccc1)[N+](=O)[O-]

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
GSR P00390 1/20 0.41
CYP2D6 P10635 1/20 0.41
KMT2A Q03164 1/20 0.39
FBP1 P09467 1/20 0.37
SRC P12931 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
LMNA P02545 2/20 0.35
MAPK1 P28482 1/20 0.35
ALDH1A1 P00352 2/20 0.35
TP53 P04637 1/20 0.35
TSHR P16473 1/20 0.35
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
CYP3A4 P08684 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9203949 0.87 GSR (0.37) GSRCYP2D6KMT2AFBP1SRC
SCHEMBL10976703 0.86 GSR (0.39) GSRCYP2D6KMT2AFBP1SRC
SCHEMBL286963 0.85 GSR (0.43) GSRCYP2D6KMT2ASRCLMNA
SCHEMBL22323630 0.85 GSR (0.43) GSRCYP2D6KMT2ASRCLMNA
SCHEMBL5932816 0.84 GSR (0.42) GSRCYP2D6KMT2ASRCLMNA
SCHEMBL10517386 0.83 GSR (0.39) GSRCYP2D6KMT2ASRCSMN1; SMN2
SCHEMBL5932183 0.82 GSR (0.41) GSRCYP2D6KMT2ASRCLMNA
SCHEMBL3299147 0.82 ALDH1A1 (0.49) GSRCYP2D6KMT2AFBP1SRC
SCHEMBL10640253 0.82 GSR (0.41) GSRCYP2D6KMT2ASRCLMNA
SCHEMBL38107 0.82 NPSR1 (0.43) GSRCYP2D6SRCSMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 500 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118420691-B Avermectin derivative containing nitrobenzyl oxycarbonyl ester and its synthesis and use 内蒙古嘉宝仕生物科技股份有限公司 2024-09-17 CN claimed
CN-118420691-A Avermectin derivative containing nitrobenzyl oxycarbonyl ester and its synthesis and use 内蒙古嘉宝仕生物科技股份有限公司 2024-08-02 CN claimed
CN-109627236-A Optoacoustic probe and the preparation method and application thereof for In vivo detection nitroreductase 华南师范大学 2019-04-16 CN claimed
EP-0804413-A1 NITROGEN MUSTARD PRODRUGS WITH NOVEL LIPOPHILIC PROTECTING GROUPS, AND PROCESSES FOR THEIR PRODUCTION CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1997-11-05 EP claimed
WO-1996022277-A1 NITROGEN MUSTARD PRODRUGS WITH NOVEL LIPOPHILIC PROTECTING GROUPS, AND PROCESSES FOR THEIR PRODUCTION CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1996-07-25 WO claimed
US-12637495-B2 De-immunized Shiga toxin a subunit effector polypeptides for applications in mammals MOLECULAR TEMPLATES, INC. (US) 2026-05-26 US disclosed
US-20260034230-A1 COMPOSITIONS AND METHODS FOR TRANSFERRIN RECEPTOR (TFR)-MEDIATED DELIVERY TO THE BRAIN AND MUSCLE REGENERON PHARMACEUTICALS, INC. (US) 2026-02-05 US disclosed
US-20260028372-A1 PROTEIN EXTRACTION, PROTEIN IDENTIFICATION, AND SPATIAL PROTEOMICS USING PHOTOCLEAVABLE ANCHOR IN SWELLABLE MATERIAL MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2026-01-29 US disclosed
EP-4619438-A2 COMPOSITIONS AND METHODS FOR FIBROBLAST GROWTH FACTOR RECEPTOR 3-MEDIATED DELIVERY TO ASTROCYTES Regeneron Pharmaceuticals, Inc. (US) 2025-09-24 EP disclosed
US-12365927-B2 Engineered ketoreductase polypeptides CODEXIS, INC. (US) 2025-07-22 US disclosed
EP-4561636-A1 COMPOSITIONS AND METHODS FOR TRANSFERRIN RECEPTOR (TFR)-MEDIATED DELIVERY TO THE BRAIN AND MUSCLE Regeneron Pharmaceuticals, Inc. (US) 2025-06-04 EP disclosed
US-20250051474-A1 ANTI-CD97 ANTIBODIES AND ANTIBODY-DRUG CONJUGATES NEW YORK UNIVERSITY (US) 2025-02-13 US disclosed
EP-0180252-A1 Process of preparing azetidinone compounds SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1986-05-07 EP disclosed
EP-0010316-B1 1-, 6- AND 2-SUBSTITUTED-1-CARBA-2-PENEM-3-CARBOXYLIC ACIDS, PROCESS FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME MERCK & CO. INC. (US) 1983-10-05 EP disclosed
EP-0073451-A2 Carbapenam compound and processes for the preparation thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1983-03-09 EP disclosed
EP-0054917-A2 6- and 4-Substituted-1-azabicyclo(3.2.0)heptan-3,7-dione-2-carboxylates MERCK & CO. INC. (US) 1982-06-30 EP disclosed
US-4309346-A INTERMEDIATES FOR AMINO ACID DERIVATIVE ANTIBIOTICS MERCK & CO., INC. (US) 1982-01-05 US disclosed
US-4260627-A 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids MERCK & CO., INC. (US) 1981-04-07 US disclosed
EP-0010316-A1 1-, 6- and 2-substituted-1-carba-2-penem-3-carboxylic acids, process for preparing the same and pharmaceutical compositions containing the same MERCK & CO. INC. (US) 1980-04-30 EP disclosed
EP-0001628-A1 3-Substituted-6-substituted-7-oxo-1-azabicyclo (3.2.0)-hept-2-ene-2-carboxylic acid, its preparation and pharmaceutical compositions containing it MERCK & CO. INC. (US) 1979-05-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12637495-B2 De-immunized Shiga toxin a subunit effector polypeptides for applications in mammals FCGRT, CD2, CD22 GSR 4496/4885CYP2D6 4838/4885KMT2A 2666/4885
US-20260034230-A1 COMPOSITIONS AND METHODS FOR TRANSFERRIN RECEPTOR (TFR)-MEDIATED DELIVERY TO THE BRAIN AND MUSCLE MUSK, TFRC, MYOF GSR 1006/4885CYP2D6 2526/4885KMT2A 1699/4885
US-20260028372-A1 PROTEIN EXTRACTION, PROTEIN IDENTIFICATION, AND SPATIAL PROTEOMICS USING PHOTOCLEAVABLE ANCHOR IN SWELLABLE MATERIAL SRMS, EPCAM, PTMS GSR 3164/4885CYP2D6 3624/4885KMT2A 1515/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.