Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | DGKA | P23743 | 3/20 | 0.37 |
| ▸ | DGKZ | Q13574 | 3/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13955139 | 0.83 | OPRD1 (0.50) | SIGMAR1OPRD1OPRM1OPRK1OPRL1 | |
| SCHEMBL21831126 | 0.75 | SIGMAR1 (0.54) | SIGMAR1OPRD1OPRM1OPRK1OPRL1 | |
| SCHEMBL21831659 | 0.75 | SIGMAR1 (0.54) | SIGMAR1OPRD1OPRM1OPRK1OPRL1 | |
| SCHEMBL7427589 | 0.75 | SIGMAR1 (0.54) | SIGMAR1OPRD1OPRM1OPRK1OPRL1 | |
| SCHEMBL25327760 | 0.75 | SIGMAR1 (0.54) | SIGMAR1OPRD1OPRM1OPRK1OPRL1 | |
| SCHEMBL7430109 | 0.75 | SIGMAR1 (0.54) | SIGMAR1OPRD1OPRM1OPRK1OPRL1 | |
| SCHEMBL25328640 | 0.75 | SIGMAR1 (0.54) | SIGMAR1OPRD1OPRM1OPRK1OPRL1 | |
| SCHEMBL7427594 | 0.75 | SIGMAR1 (0.54) | SIGMAR1OPRD1OPRM1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL21831397 | 0.74 | SIGMAR1 (0.53) | SIGMAR1OPRD1OPRM1OPRK1OPRL1 | |
| SCHEMBL9256532 | 0.74 | SIGMAR1 (0.38) | SIGMAR1OPRD1OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11713316-B2 | Substituted naphthyridinone compounds useful as T cell activators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11713316-B2 | Substituted naphthyridinone compounds useful as T cell activators | DGKZ, DGKA, DGKG | SIGMAR1 3220/4885OPRD1 2019/4885OPRM1 4240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.