SCHEMBL2590198

SCHEMBL2590198

COCCc1cc(C(=O)O)cc(=O)[nH]1

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.49
GPR84 Q9NQS5 12/20 0.38
ALDH1A1 P00352 2/20 0.38
LMNA P02545 1/20 0.37
CYP1A2 P05177 1/20 0.37
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA3 P07451 1/20 0.36
PKM P14618 1/20 0.36
CA4 P22748 1/20 0.36
CA6 P23280 1/20 0.36
CA5A P35218 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
CA14 Q9ULX7 1/20 0.36
CA5B Q9Y2D0 1/20 0.36
CCNO P22674 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4649358 0.86 TSHR (0.40) GPR84
SCHEMBL2585300 0.86 CYP1A2 (0.42) HCAR2GPR84ALDH1A1LMNACYP1A2
SCHEMBL9412488 0.83 MAPT (0.53) HCAR2GPR84ALDH1A1LMNACYP1A2
SCHEMBL8885796 0.81 MPO (0.51) HCAR2GPR84ALDH1A1LMNA
SCHEMBL3676992 0.79 GPR84 (0.55) HCAR2GPR84
SCHEMBL56627 0.78 ALDH1A1 (0.44) HCAR2GPR84ALDH1A1LMNA
SCHEMBL3672125 0.74 ALDH1A1 (0.37) GPR84ALDH1A1LMNACCNO
SCHEMBL14966592 0.74 GPR84 (0.67) GPR84
SCHEMBL23684463 0.73 GPR84 (0.43) GPR84ALDH1A1LMNA
SCHEMBL6612480 0.72 SMN1; SMN2 (0.40) GPR84ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2595989-A1 HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS Vertex Pharmaceuticals Incorporated (US) 2013-05-29 EP disclosed
WO-2013067248-A1 BENZOXAZINES AS MODULATORS OF ION CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2013-05-10 WO disclosed
WO-2011140425-A1 HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2011-11-10 WO disclosed