Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TPMT | P51580 | 1/20 | 0.35 |
| ▸ | NMT1 | P30419 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 3/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.32 |
| ▸ | HTR3B | O95264 | 1/20 | 0.32 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL114694 | 0.96 | — | — | |
| SCHEMBL151031 | 0.89 | — | — | |
| 1,3,5-Trichlorobenzene SCHEMBL865477 | 0.89 | TSHR (0.61) | TSHRCYP3A4TP53ALDH1A1TPMT | |
| SCHEMBL11804897 | 0.80 | ALDH1A1 (0.39) | TSHRALDH1A1 | |
| SCHEMBL20293122 | 0.80 | TSHR (0.35) | TSHR | |
| SCHEMBL29999249 | 0.78 | TSHR (0.40) | TSHRCYP3A4TP53ALDH1A1IDO1 | |
| SCHEMBL3983596 | 0.78 | TSHR (0.40) | TSHRCYP3A4TP53ALDH1A1IDO1 | |
| SCHEMBL28894230 | 0.78 | TSHR (0.40) | TSHRCYP3A4TP53IDO1HTR3E | |
| SCHEMBL15517049 | 0.76 | TSHR (0.38) | TSHRCYP3A4TP53ALDH1A1IDO1 | |
| SCHEMBL1363469 | 0.76 | PNMT (0.46) | TSHRCYP3A4TP53IDO1HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114920774-B | D-A type triarylphosphine compound and synthetic method and application thereof | 哈尔滨工业大学（深圳） | 2024-01-02 | — | — | CN | disclosed |
| CN-114920774-A | D-A type triarylphosphine compound and synthetic method and application thereof | 哈尔滨工业大学（深圳） | 2022-08-19 | — | — | CN | disclosed |
| EP-2563764-B1 | NOVEL SPIROPIPERIDINE PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-02-25 | — | — | EP | disclosed |
| US-8785634-B2 | Spiropiperidine prolylcarboxypeptidase inhibitors | MERCK SHARP & DOHME CORP (US) | 2014-07-22 | — | — | US | disclosed |
| US-8618173-B2 | Insecticidal compounds | SYNGENTA CROP PROTECTION, LLC (US) | 2013-12-31 | — | — | US | disclosed |
| WO-2013110313-A1 | SELECTIVE ALLOSTERIC MODULATORS OF THE SEROTONIN TRANSPORTER | H. LUNDBECK A/S (DK) | 2013-08-01 | — | — | WO | disclosed |
| EP-2563764-A1 | NOVEL SPIROPIPERIDINE PROLYLCARBOXYPEPTIDASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-03-06 | — | — | EP | disclosed |
| US-20130023515-A1 | NOVEL SPIROPIPERIDINE PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2013-01-24 | — | — | US | disclosed |
| WO-2011137024-A1 | NOVEL SPIROPIPERIDINE PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-11-03 | — | — | WO | disclosed |
| US-20100240712-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-09-23 | — | — | US | disclosed |
| US-20030073703-A1 | Glucocortiocoid-selective antinflammatory agents | ABBOTT LABORATORIES AND LIGAND PHARMACEUTICALS INCORPORATED | 2003-04-17 | — | — | US | disclosed |
| EP-1299392-A2 | GLUCOCORTIOCOID-SELECTIVE ANTIINFLAMMATORY AGENTS | Abbott Laboratories (US) | 2003-04-09 | — | — | EP | disclosed |
| US-6506766-B1 | A pharmaceutical composition for use in treating inflammation, immune, autoimmune, and inflammatory diseases in a mammal by selectively modulating the activation, repression, agonism, and antagonism effects of the mammal's glucocorticoid | ABBOTT LABORATORIES | 2003-01-14 | — | — | US | disclosed |
| EP-1053239-B1 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LAB (US) | 2003-01-08 | — | — | EP | disclosed |
| WO-2002002565-A2 | GLUCOCORTIOCOID-SELECTIVE ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 2002-01-10 | — | — | WO | disclosed |
| CN-1297451-A | Glucocorticoid-selective antiinflammatory agents | ABBOTT LAB (US) | 2001-05-30 | — | — | CN | disclosed |
| CN-1063440-C | Process for the desulfurization and the desalting of fossil fuels | RHONE ROULENC AGROCHIMIE CORP (FR) | 2001-03-21 | — | — | CN | disclosed |
| EP-1053239-A1 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 2000-11-22 | — | — | EP | disclosed |
| WO-1999041256-A1 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1999-08-19 | — | — | WO | disclosed |
| CN-1079735-A | Arylpyrazole mycocide | ENERGY BIOSYSTEMS CORP (FR) | 1993-12-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073703-A1 | Glucocortiocoid-selective antinflammatory agents | NR3C1, GPR119, MC2R | TSHR 340/4885CYP3A4 4325/4885TP53 4847/4885 |
| US-20130023515-A1 | NOVEL SPIROPIPERIDINE PROLYLCARBOXYPEPTIDASE INHIBITORS | PRCP, PREP, PEPD | TSHR 2375/4885CYP3A4 843/4885TP53 4402/4885 |
| US-20100240712-A1 | INSECTICIDAL COMPOUNDS | CHRM1, CHRM2, ACHE | TSHR 2635/4885CYP3A4 332/4885TP53 3572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.