Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 2/20 | 0.35 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2593528 | 0.77 | PPARG (0.41) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL2594821 | 0.76 | HCRTR2 (0.50) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL7706427 | 0.68 | ALDH1A1 (0.46) | KDM4EALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL17437846 | 0.65 | HTR4 (0.56) | HTR4CYP3A4CYP2D6 | |
| SCHEMBL31716228 | 0.64 | LMNA (0.40) | ALDH1A1MEN1KMT2AHSD17B10POLB | |
| SCHEMBL1964214 | 0.64 | LMNA (0.40) | ALDH1A1MEN1KMT2AHSD17B10POLB | |
| SCHEMBL67237 | 0.64 | LMNA (0.59) | ALDH1A1MEN1MAPTKMT2AHSD17B10 | |
| SCHEMBL65737 | 0.64 | LMNA (0.59) | ALDH1A1MEN1MAPTKMT2AHSD17B10 | |
| SCHEMBL1715 | 0.64 | LMNA (0.59) | ALDH1A1MEN1MAPTKMT2AHSD17B10 | |
| SCHEMBL20769804 | 0.64 | LMNA (0.59) | ALDH1A1MEN1MAPTKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |