Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10053462 | 0.77 | CA12 (0.42) | RAB9AALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL12164545 | 0.75 | CYP1A2 (0.43) | NPC1RAB9AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL67498 | 0.75 | ALDH1A1 (0.61) | NPC1RAB9AALDH1A1CYP3A4MAPK1 | |
| SCHEMBL29950410 | 0.75 | ALDH1A1 (0.61) | NPC1RAB9AALDH1A1CYP3A4MAPK1 | |
| SCHEMBL340086 | 0.75 | NPC1 (0.60) | NPC1RAB9AALDH1A1CYP3A4MAPK1 | |
| SCHEMBL929945 | 0.71 | CYP3A4 (0.56) | NPC1RAB9AALDH1A1CYP3A4MAPK1 | |
| SCHEMBL581508 | 0.71 | TUBB4A (0.63) | NPC1RAB9AALDH1A1CYP3A4MAPK1 | |
| SCHEMBL12809824 | 0.71 | ERN1 (0.41) | NPC1RAB9AALDH1A1CYP3A4TRIM24 | |
| SCHEMBL1620598 | 0.70 | NPC1 (0.53) | NPC1RAB9AALDH1A1CYP3A4MAPK1 | |
| SCHEMBL1000565 | 0.70 | NPC1 (0.53) | NPC1RAB9AALDH1A1CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |